Could it be that making the sustained effort had a placating effect, i.e. similar to placebo effect, that the trial participants would have had an 'upturn' irrespective of methylation; or substitute another regimen, say Dr, Coimbra's Vit D3 protocol?
I spent a lot of time and expense with both processes, in specific reading 'Dr. Amy's' questionable books and web routines but succeeded in affecting little but abating the focus on symptoms while preoccupied with the process. While symptoms ultimately returned, that is not to say there may have been some health benefits to 'M' and
the Vitamin D3 protocol... .
IMO, methylation is just another fad that got a few people engaged then withered away, like so many other 'cure de jours'. Even capsules ordered from the guru's
store ultimately hardened and blackened with spots! ...But hey, no ticky, no washy; you gotta try... .