sometexan84
Senior Member
- Messages
- 1,195
I posted a thread a while back, about how I stopped all my meds and supplements to see what would happen.
I stopped them all in March 2021. And new symptoms and conditions began manifesting pretty quickly.
I got Uveitis, Psoriatic Arthritis, Small Fiber Neuropathy, and Alopecia Areata.
Kind of randomly, I decided to see if there were any published studies showing the relationship between these conditions and Enterovirus related gut disturbances.
Persistent Enterovirus in the intestinal epithelium is the #1 infection most frequently found in ME/CFS (followed by EBV and HHV-6 as #2 and #3). It leads to intestinal permeability, gut dysbiosis, immune dysfunction, the works.
Anyway, again, kind of randomly, I googled the following...
"uveitis intestinal permeability"
"psoriatic arthritis intestinal permeability"
"small fiber neuropathy intestinal permeability"
"alopecia areata intestinal permeability"
Was not thinking I'd find what I did. Turns out, every single one is related to the gut issues that arise from the persistent EV infection. Intestinal dysbiosis and intestinal permeability are massive contributors.
These are the notes I made from the Google searches...
(not much on Enterovirus specifically in these notes, as I already know how it causes these disturbances... I do have many months worth of documentation on that though, if anyone's interested.)
(non-infectious) Uveitis – associated w/ intestinal dysbiosis
I stopped them all in March 2021. And new symptoms and conditions began manifesting pretty quickly.
I got Uveitis, Psoriatic Arthritis, Small Fiber Neuropathy, and Alopecia Areata.
Kind of randomly, I decided to see if there were any published studies showing the relationship between these conditions and Enterovirus related gut disturbances.
Persistent Enterovirus in the intestinal epithelium is the #1 infection most frequently found in ME/CFS (followed by EBV and HHV-6 as #2 and #3). It leads to intestinal permeability, gut dysbiosis, immune dysfunction, the works.
Anyway, again, kind of randomly, I googled the following...
"uveitis intestinal permeability"
"psoriatic arthritis intestinal permeability"
"small fiber neuropathy intestinal permeability"
"alopecia areata intestinal permeability"
Was not thinking I'd find what I did. Turns out, every single one is related to the gut issues that arise from the persistent EV infection. Intestinal dysbiosis and intestinal permeability are massive contributors.
These are the notes I made from the Google searches...
(not much on Enterovirus specifically in these notes, as I already know how it causes these disturbances... I do have many months worth of documentation on that though, if anyone's interested.)
(non-infectious) Uveitis – associated w/ intestinal dysbiosis
- Mice w/ uveitis successfully treated by modifying the intestinal microbiota, such as oral antibiotics or administration of oral short chain fatty acids (SCFAs)
- The treatment reduces ocular inflammation via enhancement of regulatory T cells, decreasing intestinal permeability, and/or affecting T cell trafficking between the intestines and the spleen
- Commensal gut bacteria are influential in systemic and intestinal mucosal immunity and thus contribute to the development of extraintestinal inflammation like uveitis
- Gut dysbiosis has been associated w/ “sickness behavior” and chronic fatigue.
- CFS and severe mental illness patients have increased circulating levels of the tight-junction protein zonulin, the endotoxin LPS, the gut related systemic inflammatory proteins LBP and sCD14, antibodies against endotoxins, and the acute phase protein A-1-AT
- Zonulin is a tight-junction protein and key regulator of intestinal permeability, with increased circulating levels suggesting a compromised intestinal barrier
- Improved on probiotics, improvements stopped post-treatment
- All Psoriatic Arthritis patients showed increased levels of the enteric permeability marker zonulin which correlated with the frequency of peripheral Th17 cells
- Also, more evidence between gut microbiota and intestinal permeability. Balanced microbiome is needed for tight epithelial barrier and functional immune system
- Fiber and SCFA – This is yet another article that highlights fiber and SCFA in this regard…
- “A high intake of fibers affects the make up of the intestinal microbiota, primarily increasing short-chain fatty acid concentrations that have beneficial immunomodulatory effects (eg increasing Treg numbers and function)”
- Focus here was children w/ T1D
- Though EVB and EVA were both found, EV A was actually the most frequent, w/ CVA2, A4 and A16 at the top of the list
- Article focuses mostly on neuropathic pain in stuff like SFN and fibromyalgia. But connects to gut, the microbiota-gut-brain axis, neurotransmitters, enteric nervous system, CNS disturbances, and a lot of the ME/CFS usual suspects.
- Impairment of the innate immune functions of intestinal epithelial cells is associated with intestinal inflammation
- Intestinal epithelial cells help maintain a healthy relationship between gut microbiota and host immunity
- IECs help segregate (or separate) gut bacteria from immune cells (in intestinal lumen and lamina propria), to prevent conflict here, that would result in intestinal inflammation
- Cytokines and Intestinal Epithelial Cells
- IL-17 and IL-22 produced by Th17 cells upregulate the secretion of AMPs (Antimicrobial peptides) and Reg3 in IECs to help control gut microbiota
- IL-6 (from intraepithelial lymphocytes) enhances IEC proliferation and contributes to healing from mucosal injury
- (TNF)-α and (IFN)-γ, inhibit epithelial cell proliferation through the suppression of β-catenin/T cell factor (TCF) signaling
- Th2 cytokines (IL-5 and IL-13) contributes to epithelial cell proliferation
- IL-13 promotes apoptosis of IECs, leading to mucosal barrier disturbance