I came across this paper: https://www.nature.com/articles/d41586-020-02713-7 which is about glial cells damping neurons. The following bit might apply to PWME, since ME seems to involve the glial cells:
"ADO derived from ATP released by astrocytes is proposed to regulate sleep onset10. Badimon et al. found that the extracellular level of ADO in a brain region called the striatum was reduced by 85% in anaesthetized mice lacking microglia, compared with control mice that had microglia. This suggests that the build-up of extracellular ADO that generates sleep pressure might largely be derived from the activity of microglial CD39. Thus, microglia-facilitated negative-feedback control of neuronal activity could be a side effect of the evolution of a system to induce sleep (or vice versa)."
I'm not sure how to apply that to improve our sleep, but it's a possible lead for further research.
"ADO derived from ATP released by astrocytes is proposed to regulate sleep onset10. Badimon et al. found that the extracellular level of ADO in a brain region called the striatum was reduced by 85% in anaesthetized mice lacking microglia, compared with control mice that had microglia. This suggests that the build-up of extracellular ADO that generates sleep pressure might largely be derived from the activity of microglial CD39. Thus, microglia-facilitated negative-feedback control of neuronal activity could be a side effect of the evolution of a system to induce sleep (or vice versa)."
I'm not sure how to apply that to improve our sleep, but it's a possible lead for further research.