Cort
Phoenix Rising Founder
- Messages
- 7,392
Behav Brain Res. 2009 Jul 27. [Epub ahead of print] Links
Epigallocatechin gallate ameliorates chronic fatigue syndrome in mice: Behavioral and Biochemical Evidence.
They basically gave these mice what they believe is chronic fatigue syndrome by injecting them with lipopolysaccharides - which are, as I remember, bacterial toxins. After they did this the mice had increased fatigue, less mobility, etc. and increased oxidative stress and increased pro-inflammatory cytokine production.
Simply by giving the mice epigallocatechin gallate the mice recovered from their reaction to the pathogenic toxins; their fatigue disappeared in the size of oxidative stress and inflammation did as well.
Another study found that it increased endurance in fatigued mice as well.
http://www.ncbi.nlm.nih.gov/pubmed/18455659?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
Epig....gallate is found in Green tea extract. Interestingly given our recent discussion of mesenchymal cells and Dr. Cheney's use of them epi...gallate has been shown to possibly increase the viability of those treatments.
http://www.ncbi.nlm.nih.gov/pubmed/19640263?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
This study notes that the bioavailability of epi...gallate is generally low but that it can be boosted with quercetin and red onions(!)(?)
http://www.ncbi.nlm.nih.gov/pubmed/19585479?ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
Anyone ever try green tea extract?
Epigallocatechin gallate ameliorates chronic fatigue syndrome in mice: Behavioral and Biochemical Evidence.
They basically gave these mice what they believe is chronic fatigue syndrome by injecting them with lipopolysaccharides - which are, as I remember, bacterial toxins. After they did this the mice had increased fatigue, less mobility, etc. and increased oxidative stress and increased pro-inflammatory cytokine production.
Simply by giving the mice epigallocatechin gallate the mice recovered from their reaction to the pathogenic toxins; their fatigue disappeared in the size of oxidative stress and inflammation did as well.
The present study was designed to evaluate the effects of the epigallocatechin gallate in a mouse model of immunologically-induced chronic fatigue. On 19th day, after lipopolysaccharide/Brucella abortus administration, the mice showed significant increase in immobility period, post swim fatigue and thermal hyperalgesia. Behavioral deficits were coupled with enhanced oxidative-nitrosative stress as evident by increased lipid peroxidation, nitrite levels and decreased endogenous antioxidant enzymes (superoxide dismutase, reduced glutathione and catalase) and inflammation (increased levels of tumor necrosis factor-alpha and tissue growth factor-beta). Chronic treatment with epigallocatechin gallate restored these behavioral and biochemical alterations in mice. The present study points out towards the beneficial effect of epigallocatechin gallate in the amelioration of chronic fatigue syndrome and thus may provide a new, effective and powerful strategy to treat chronic fatigue syndrome.
Another study found that it increased endurance in fatigued mice as well.
http://www.ncbi.nlm.nih.gov/pubmed/18455659?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
Epig....gallate is found in Green tea extract. Interestingly given our recent discussion of mesenchymal cells and Dr. Cheney's use of them epi...gallate has been shown to possibly increase the viability of those treatments.
http://www.ncbi.nlm.nih.gov/pubmed/19640263?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
This study notes that the bioavailability of epi...gallate is generally low but that it can be boosted with quercetin and red onions(!)(?)
http://www.ncbi.nlm.nih.gov/pubmed/19585479?ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
Anyone ever try green tea extract?