Firestormm
Senior Member
- Messages
- 5,055
- Location
- Cornwall England
Genetic associations of fatigue and other symptom domains of the acute sickness response to infection
Brain Behav Immun. 2011 Dec 29. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/22227623
Piraino B, Vollmer-Conna U, Lloyd AR.
Source: Inflammation and Infection Research Centre, School of Medical Sciences, University of New South Wales, Australia.
Abstract
The acute sickness response to infection is a conserved set of changes in physiology and behaviour, featuring fever, fatigue, musculo-skeletal pain, disturbed mood, and cognitive difficulties.
The manifestations differ somewhat between individuals, including those infected with pathogens which do not have genetic variability - suggesting host determinants.
Principal components analysis (PCA) was applied to acute phase, self-report symptom data from subjects in the Dubbo Infection Outcomes Study* (n=296) to empirically derive indices of fatigue, pain, neurocognitive difficulties, and mood disturbance, as well as overall illness severity.
Associations were sought with functional single nucleotide polymorphisms (SNPs) in the cytokine genes, interleukin (IL)-6, tumour necrosis factor (TNF)-?, interferon (IFN)-?, and IL-10.
The summed individual symptom indices correlated with overall severity and also with functional status. The relative contribution of individual symptom domains to the overall illness was stable over time within subjects, but varied between subjects with the same infection.
The T allele of the IFN-? +874 T/A SNP was associated with increased fatigue (p=0.0003; OR: 3.3). The C allele of the IL-10 -592 C/A SNP exerted a protective effect on neurocognitive difficulties (p=0.017; OR: 0.52); while the A allele for the IL-10 -592 SNP was associated with increased mooddisturbance (p=0.044; OR: 1.83), as was the G allele of the IL-6 -174 G/C SNP (p=0.051; OR: 1.83).
The acute sickness response has discrete symptom domains including fatigue, which have unique genetic associations. These data provide novel insights into the pathophysiology of fatigue states.'
Copyright 2012. Published by Elsevier Inc.
(*From Dr Shepherd MEA (https://www.facebook.com/pages/ME-Association/171411469583186) this morning:
'The Dubbo Infection Outcomes Study was originally published in 2006 in conjunction with the CDC. The study was initiated as a Post-Infective Fatigue: A Model for Chronic Fatigue Syndrome according to the Federal Register. http://www.thefederalregister.com/d.p/2001-01-25-01-2269.
The first study was published in the BMJ. <http://preview.ncbi.nlm.nih.gov/pubmed/16950834#> 2006
Sep 16;333(7568):575. Epub 2006 Sep 1. Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569956/?tool=pubmed
The authors concluded: "A relatively uniform post-infective fatigue syndrome persists in a significant minority of patients for six months or more after clinical infection with several different viral and non-viral micro-organisms. Post-infective fatigue syndrome is a valid illness model for investigating one pathophysiological pathway to chronic fatigue syndrome."
Other papers published using this cohort can be found here: http://preview.ncbi.nlm.nih.gov/pubmed?term=Dubbo+Infection+Outcomes+Study'
He concludes 'This research links in with the study on fatigue markers in Sjogren's syndrome - a condition which has a number of symptomatic and pathological abnormalities in common with ME/CFS - that the MRC is funding in its new ME/CFS research portfolio.')
Brain Behav Immun. 2011 Dec 29. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/22227623
Piraino B, Vollmer-Conna U, Lloyd AR.
Source: Inflammation and Infection Research Centre, School of Medical Sciences, University of New South Wales, Australia.
Abstract
The acute sickness response to infection is a conserved set of changes in physiology and behaviour, featuring fever, fatigue, musculo-skeletal pain, disturbed mood, and cognitive difficulties.
The manifestations differ somewhat between individuals, including those infected with pathogens which do not have genetic variability - suggesting host determinants.
Principal components analysis (PCA) was applied to acute phase, self-report symptom data from subjects in the Dubbo Infection Outcomes Study* (n=296) to empirically derive indices of fatigue, pain, neurocognitive difficulties, and mood disturbance, as well as overall illness severity.
Associations were sought with functional single nucleotide polymorphisms (SNPs) in the cytokine genes, interleukin (IL)-6, tumour necrosis factor (TNF)-?, interferon (IFN)-?, and IL-10.
The summed individual symptom indices correlated with overall severity and also with functional status. The relative contribution of individual symptom domains to the overall illness was stable over time within subjects, but varied between subjects with the same infection.
The T allele of the IFN-? +874 T/A SNP was associated with increased fatigue (p=0.0003; OR: 3.3). The C allele of the IL-10 -592 C/A SNP exerted a protective effect on neurocognitive difficulties (p=0.017; OR: 0.52); while the A allele for the IL-10 -592 SNP was associated with increased mooddisturbance (p=0.044; OR: 1.83), as was the G allele of the IL-6 -174 G/C SNP (p=0.051; OR: 1.83).
The acute sickness response has discrete symptom domains including fatigue, which have unique genetic associations. These data provide novel insights into the pathophysiology of fatigue states.'
Copyright 2012. Published by Elsevier Inc.
(*From Dr Shepherd MEA (https://www.facebook.com/pages/ME-Association/171411469583186) this morning:
'The Dubbo Infection Outcomes Study was originally published in 2006 in conjunction with the CDC. The study was initiated as a Post-Infective Fatigue: A Model for Chronic Fatigue Syndrome according to the Federal Register. http://www.thefederalregister.com/d.p/2001-01-25-01-2269.
The first study was published in the BMJ. <http://preview.ncbi.nlm.nih.gov/pubmed/16950834#> 2006
Sep 16;333(7568):575. Epub 2006 Sep 1. Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569956/?tool=pubmed
The authors concluded: "A relatively uniform post-infective fatigue syndrome persists in a significant minority of patients for six months or more after clinical infection with several different viral and non-viral micro-organisms. Post-infective fatigue syndrome is a valid illness model for investigating one pathophysiological pathway to chronic fatigue syndrome."
Other papers published using this cohort can be found here: http://preview.ncbi.nlm.nih.gov/pubmed?term=Dubbo+Infection+Outcomes+Study'
He concludes 'This research links in with the study on fatigue markers in Sjogren's syndrome - a condition which has a number of symptomatic and pathological abnormalities in common with ME/CFS - that the MRC is funding in its new ME/CFS research portfolio.')