There is a long-standing interest in exploring the relationship between blood-based biomarkers and psychiatric disorders, despite their causal role being difficult to resolve in observational studies.
In this study, we leverage genome-wide association study data for a large panel of heritable serum biochemical traits to refine our understanding of causal effect in biochemical-psychiatric trait pairings.
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We also demonstrated evidence that there may be a causal relationship on psychiatric phenotypes through circulating C-reactive protein (CRP), glucose and urate, which may have direct implications for clinical practice
