Genetic: a causal relationship on psychiatric phenotypes through circulating CRP, glucose, and urate. 2022

pattismith

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(PDF) Genetic estimates of correlation and causality between blood-based biomarkers and psychiatric disorders (researchgate.net)

There is a long-standing interest in exploring the relationship between blood-based biomarkers and psychiatric disorders, despite their causal role being difficult to resolve in observational studies.

In this study, we leverage genome-wide association study data for a large panel of heritable serum biochemical traits to refine our understanding of causal effect in biochemical-psychiatric trait pairings.
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We also demonstrated evidence that there may be a causal relationship on psychiatric phenotypes through circulating C-reactive protein (CRP), glucose and urate, which may have direct implications for clinical practice


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The putative effect of urate and glucose on cognition and ADHD, respectively, may have direct implications for drug repurposing given that compounds that modulate these traits are readily available. Both of these relationships are also supported by previous observational data (33)(34)(35).

Data from an incident cohort study that treated individuals with urate-lowering compounds allopurinol and febuxostat demonstrated evidence of a risk-decreasing effect on dementia, supporting the deleterious effect of urate on general cognitive function (36)