• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To become a member, simply click the Register button at the top right.

Genes, Infection, Altered Microbiota Lead to Chronic Inflammatory Disease

Gemini

Senior Member
Messages
1,176
Location
East Coast USA
Acute infection can drive long-term immune & microbiota changes leading to chronic inflammatory disease in genetically pre-disposed individuals:

www.ncbi.nlm.nih.gov/pubmed/26764594/

This is a unified "hit- and-run" model involving genetic & metabolic signals, acute infection ultimately cleared, & "altered" microbiota-- in humans (it would appear)-- leading to chronic inflammatory disease.

A similar model has been discussed by ME/CFS researchers over the years, incl. Mady Horning.

Unfortunately the paper is behind a paywall. I'm curious about how prevalent the TLR1 genetic deficiency is; what specific inflammatory diseases the model applies to; and specifics about the treatments: gene deletion and targeted probiotics.

Wonder if the collaborators at the Univ of Chicago, Argonne Nat'l Laboratory, UCLA & UC-Davis might have any insights into the pathophysiology of ME/CFS?