- Messages
- 5
- Location
- Sydney, Australia
Curios to know what work has been conducted with regards to Gene Expression or Gene therapy with CFS type illnesses?
I ask because Dr Kolgenik of OMI (I'm a patient) mentioned to me something during my last Rituxan infusion about the role of gene expression in his current research which I didn't quite grasp the logic of conducting, so wondering who out there might know a bit more about Genes/Genetic Expression, MRNA.
Have always found it peculiar why there is such a diverse range of symptoms, severity of symptoms, severity of illness, progression of illness, gender tilt, bell curve age of onset, context of onset if indeed there may be one, and more interestingly why some patients appear to be responding well to some current treatments and others not. In this respect I am referring to Rituxan & Valcyte as the big hitters for the moment.
Beyond what Dr Kogelnik is focusing on with regards to gene expression and the above 2 drugs (ostensibly) in an effort to better identify treatments that will most likely will prove beneficial (my interpretation), I can't help but wonder why a far greater focus on DNA/MRNA data profiling isn't top of many researchers agenda?
I'm going back some time now, but a lecturer of mine many years ago stated that when genetic profiling becomes a cost effective research tool (which it now is) then one would expect an explosion in the kinds of targeted gene therapy research and treatments there following. I've really no idea who is or isn't looking at CFS through this prism of research, but would be very interested to know who is. I ask the question because Rituxan has shown itself to have a marked benefit for a limited period of time for only some CFS patients, which has given some credence to the view that CFS has has a strong underlying genetic component, but to that end I would really like to know if anyone is doing any substantial genetic research in the context of CFS.
If anyone knows of anyone looking at this area of research I would be grateful if anyone could please send me URL links or contact information as I do believe this is an area of research worth investing in.
Thanks,
Ben
I ask because Dr Kolgenik of OMI (I'm a patient) mentioned to me something during my last Rituxan infusion about the role of gene expression in his current research which I didn't quite grasp the logic of conducting, so wondering who out there might know a bit more about Genes/Genetic Expression, MRNA.
Have always found it peculiar why there is such a diverse range of symptoms, severity of symptoms, severity of illness, progression of illness, gender tilt, bell curve age of onset, context of onset if indeed there may be one, and more interestingly why some patients appear to be responding well to some current treatments and others not. In this respect I am referring to Rituxan & Valcyte as the big hitters for the moment.
Beyond what Dr Kogelnik is focusing on with regards to gene expression and the above 2 drugs (ostensibly) in an effort to better identify treatments that will most likely will prove beneficial (my interpretation), I can't help but wonder why a far greater focus on DNA/MRNA data profiling isn't top of many researchers agenda?
I'm going back some time now, but a lecturer of mine many years ago stated that when genetic profiling becomes a cost effective research tool (which it now is) then one would expect an explosion in the kinds of targeted gene therapy research and treatments there following. I've really no idea who is or isn't looking at CFS through this prism of research, but would be very interested to know who is. I ask the question because Rituxan has shown itself to have a marked benefit for a limited period of time for only some CFS patients, which has given some credence to the view that CFS has has a strong underlying genetic component, but to that end I would really like to know if anyone is doing any substantial genetic research in the context of CFS.
If anyone knows of anyone looking at this area of research I would be grateful if anyone could please send me URL links or contact information as I do believe this is an area of research worth investing in.
Thanks,
Ben