Gastroparesis and Nutrition - Please Help!

[kangaSue]

@kangaSue You ever try BH4 for gastroparesis. There are some studies that suggest it may be helpful although the price is quite high.

Also was it you that said some nitric oxide promoting medication helped your gastroparesis?

The clinical trial results of a new line of BH4 med (sepiapterin) aimed at gastroparesis were posted recently and are looking promising. They were looking into its effect on impaired gastric accommodation in diabetic women but that's a symptom that also occurs in idiopathic gastroparesis for both sexes and interestingly, is a function that is improved just from a nitrate in some cases.
https://www.sciencedirect.com/science/article/pii/S1056872721001537 Effect of Oral CNSA-001 (sepiapterin, PTC923) on gastric accommodation in women with diabetic gastroparesis: A randomized, placebo-controlled, Phase 2 trial (2021)

 

[sb4]

The clinical trial results of a new line of BH4 med (sepiapterin) aimed at gastroparesis were posted recently and are looking promising. They were looking into its effect on impaired gastric accommodation in diabetic women but that's a symptom that also occurs in idiopathic gastroparesis for both sexes and interestingly, is a function that is improved just from a nitrate in some cases.
https://www.sciencedirect.com/science/article/pii/S1056872721001537 Effect of Oral CNSA-001 (sepiapterin, PTC923) on gastric accommodation in women with diabetic gastroparesis: A randomized, placebo-controlled, Phase 2 trial (2021)

Maybe a year ago I tried a supplement that was very expensive and contained a small amount of BH4. I took it in high doses for a couple of days to make sure I got a decent dose. Unfortunately didn't notice anything, perhaps it was a bad supplement, or it didn't get to the proper places. I think I was trying to do it sublingually though it wasn't meant for that.

I came across a thread by @gregh286 from a while back where he took a workout formula nitric oxide supplement and achieved results. I have bought a similar one containing L-Arginine Alpha ketoglutarate, Citruline malate Beta Alanine L Leucine L Carnitine L Tyrosine. I'll try it once my other symptoms settle down. Probably wont be as powerful as the drugs you use for gastroparesis but hopefully it will have some effect.

 

[kangaSue]

I came across a thread by @gregh286 from a while back where he took a workout formula nitric oxide supplement and achieved results. I have bought a similar one containing L-Arginine Alpha ketoglutarate, Citruline malate Beta Alanine L Leucine L Carnitine L Tyrosine. I'll try it once my other symptoms settle down. Probably wont be as powerful as the drugs you use for gastroparesis but hopefully it will have some effect.

I've tried a few different otc nitric oxide supplements, none of them sat well with my GI system so I was very surprised to tolerate a prescription NO donor med.
Haven't tried them myself but Cialis or Viagra can also work for impaired gastric accommodation for some people. The anti-anxiety med buspirone also has some clinical evidence of efficacy in this area too.
https://www.cghjournal.org/article/S1542-3565(12)00802-6/pdf

 

[Judee]

Found this recently regarding gastroparesis: https://www.hormonesmatter.com/tag/thiamine-gastroparesis/

 

[cheeseater]

Not knowing you, it sounds similar to diverticulitis. No blood tests yet to exclude an infection? Curious why you have chosen skim milk to drink? Do you always drink milk on a regular basis? Also sounds like lactose intolerance. Doctor should do some imaging to see if you have a blockage. Since I was 5 years old I could not drink milk for reasons similar to the symptoms you describe. But it is not lactose intolerance I have, because I can eat cheese and sour cream and yogurt all a want. Only drinking milk sends me over...

 

[Judee]

But it is not lactose intolerance I have, because I can eat cheese and sour cream and yogurt all a want. Only drinking milk sends me over...

I think you have that switched around a bit. It actually sounds like you are lactose intolerant because you can eat those things but not the milk.

See this WEBSITE says, "
Fermentation helps break down nutrients in food, making them easier to digest than their unfermented counterparts.
For example, lactose — the natural sugar in milk — is broken down during fermentation into simpler sugars — glucose and galactose (20).
As a result, those with lactose intolerance are generally fine eating fermented dairy like kefir and yogurt (21).

 

[cheeseater]

No, I realize that lactose intolerant people can often eat some yogurt of kefir without problems. Those are really the only exception. When I say I can eat yogurt I am talking about eating a whole quart in a day. Not something your typical person with lactose intolerance can do. Also, lactose intolerant people cannot eat most types of cheese, yet I can make a meal of it and feel no troubles. I am not lactose intolerant. I am highly sensitive to milk.