GAD1 & 2 glutamate- GABA-balance
- Thread starter Hope78
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They aren't actually marketed as GABA; they're marketed as GABAergic drugs, which means that they stimulate the production of GABA.
There's only one form of GABA, and it's not a calcium channel blocker. But as noted, it doesn't cross the BBB, so supplemental GABA will not work unless you have a leaky BBB (which many of us do).
There are various different GABAergic drugs with various side effects; benzos are also relevant here because although they don't create GABA, they increase the effects of GABA. But tolerance is a problem with all of these drugs, though the extent of the problem varies by drug. Also, many of these drugs can be extremely addicting, and must be taken with great care.
Gingergrrl
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Thanks, @alicec, and I may have a leaky BBB for all I know since in general everything seems to be "leaky" and more permeable when you have MCAS. It was just an experiment and I know it may not work and am still conflicted if I even want to try it.
@zzz Thanks and it seems like some of the supplements are marketed as a form (or precursor?) of GABA so you have to really carefully read the label. Many also contain multiple ingredients and not just GABA. If I try it, I want to find a pure form of GABA with no other ingredients... and most likely this will be another failed experiment to add to the list.
I really appreciate everyone's feedback on this issue!