Thought I would add my autonomic report to this too:-
Particulars: A 33-year old male was referred for autonomic function test with a clinical impression of: Chronic fatigue Syndrome.
Results
Cardiovascular reflexes: Resting cardiac vagal tone (CVT): was 6.57 units in the linear vagal scale (LVS) which is a normal resting cardiac vagal tone, (Normal range, 5-10 units in the LVS), associated with frequent Abnormal Spontaneous Brainstem Activation (ASBAs). There was normal spontaneous baroreflex function.
Resting heart rate: was 63 beats/min, which is a slower than normal heart rate not consistent with this resting level of CVT.
Breathing: there was normal breathing at the rate of 14 breaths/min.
Deep breathing: CVT was 11.54 units and the maximum CVT was 17.77 units in the LVS indicating over-reaction of CVT within the brainstem during deep breathing.
Carotid massage: CVT increased by 7.2 units in the LVS showing a normal cardiodepressor effect (normal increase 5-20 units), blood pressure (BP) changed by -2.3 mmHg indicating failure of the vasodepressor effect (normal drop 10-25 mmHg).
Baroreflex responsiveness in isometric exercise: was 3.80 ms/mmHg and 2.84 ms/mmHg was predicted from the patient’s height, it indicates a normal central gain of the baroreflex system.
Valsalva’s ratio: was 2.35 indicating a higher than normal Valsalva's ratio (normal range, 1.2-1.8).
Nutritive Peripheral Circulation: Supine pO2 was 70.2 (should normally be above 60 mmHg) and supine pCO2 was 43.3 mmHg (normal range; 39-44 mmHg). There was good nutritive gaseous exchange in peripheral tissues in supine position at rest. There were good gaseous responses in peripheral tissues during deep breathing.
Orthostasis: Cardiac response: showed a normal response in a 30:15 ratio test.
BP stability: was poor, systolic BP varied by -56.0 mmHg, normal variation is <25 mmHg. Mean supine arterial BP was 67.4 mmHg indicating moderate supine hypotension (the normal range of supine mean arterial BP, 80-105 mmHg).
Orthostatic hypotension: Postural change in diastolic BP was 3.3 mmHg, so no postural hypotension. There was inotropic fatigue on standing upright.
Sympathetic function in general: There was no test done for postganglionic damage. The BP evidence suggests a low baseline supine sympathetic tone. There was good baseline inotropic function.
Control of resistance blood vessels in skeletal muscles during isometric exercise: showed sympathetic failure in skeletal muscles. There was good inotropic response when sitting upright.
Cardioaccelerator function in isometric exercise: showed cardioaccelerator failure. There was poor inotropic response to isometric exercise.
Blood pressure response to Valsalva’s manoeuvre: BP change in phase IIe was -32.8 mmHg and in phase III was -30.8 mmHg showing evidence of reduced venous return. BP change in phase IIi was 17.2 mmHg indicating a slightly raised splanchnic sympathetic tone.
Interpretation: The results show evidence of sympathetic failure in skeletal muscles, cardioaccelerator failure but a slightly raised splanchnic sympathetic tone in the deep target organs of the sympathetic division of the autonomic nervous system. There was evidence of reduced venous return to the heart. In the parasympathetic division, there was normal resting cardiac vagal tone. Baroreflex system had a normal central gain but there was over-reaction of the CVT within the brainstem during deep breathing. There was normal cardiodepressor but failure of the vasodepressor effects of the carotid reflex. Of the non-specific tests, there was no postural hypotension, higher than normal Valsalva's ratio but normal response of the heart to standing upright.
Conclusion and Recommendations: This patient has a slightly raised sympathetic tone in the splanchnic vascular bed, and he has cardioaccelerator problem in the heart and sympathetic dysfunction in the skeletal muscles. The raised sympathetic tone in the splanchnic vascular bed can be compensatory to failure elsewhere, but can also be due to increased immune activity in this patient. This patient should therefore be investigated for allergy to common substances in the environment. He has normal resting central parasympathetic activity associated with skewed peripheral baroreflex function in which only the vasodepressor function is abnormal. He currently has good nutritive gaseous exchange in peripheral tissues in supine position and good gaseous responses in peripheral tissues during deep breathing. The poor inotropic response during isometric exercise means he will fatigue easily and therefore requires support of the inotropic function of the heart through dietary supplements.
My thoughts:
Since I had this test done a few months ago, I've steadily got worse. In fact no treatments whatsoever have made any apparent difference to me. Incidentally I was also diagnosed with EDS type 3 around 6 weeks ago. Which came as a huge suprise to me, as I'd never thought of myself as hypermobile, nor have I had joint problems in the past apart from sports injuries. Nethertheless I was diagnosed by one of the UK experts in it, so it is a correct diagnosis I assume. Makes me wonder how many others have this and don't even know they have it. My symptoms are primarily autonomic problems, I feel terrible after a nights sleep from lying down overnight (presumably the supine hypotension) and I cant sit or stand for very long enough. I do have fatigue but its not my worst symptom, not by a long way. I seem to have a huge amount of sympathetic excess, whihc makes my body feel likes its vibrating all over, I have this nearly the entire time. As regards the test results saying this is caused by allergy...I am not actually aware of having any allergies, never have been.