Folate / B12 / methyl donor intolerance

[Lrn5]

Any ideas at all on what can trigger a person to not be able to take folate or B12 without really bad symptoms? I have had 3 horrible years (undermedicated on thyroid bad and developed SIBO, leaky gut, high homocysteine, histamine intolerance). I used to be able to take folate but in the last couple years I cannot take ANY methyl donors or else I really feel like I'm going to die (extreme head sensations, extreme fatigue, aches, tingling - I can't even engage). I can't even eat folate fortified foods! I've also discovered I am undermethylating and not a good detoxer. Am working with a good new functional doc who HAS helped me make progress (I think mostly better because I'm finally back on a little thyroid med). Is this methylation-cycle related?

MTHFR A1298C ++
MTHFS - ST20 ++
COMT ++ (14 of them)
FUT2 - all 3 ++ so I am a nonsecretor

 

[Joopiter76]

I am in a similar situation. Getting horrible increasing symptoms from folate in any form, B12 in any form if more than 5yg which is „nothing“, B5 and B1 if more than just less than usual daily needed dose.
Can‘t tolerate most meds. My legs turned numb, my knee reflexes went away, mostly bedbound now.
Only thing that helps is Lorazepam and zopiclon. Without that this disease would be unbearable for me. And even so it is hard enough Both stimulate Gaba receptor.
I ha proven severe mitochondrial dysfunction with morphological changes and damages, partly blockage of eletron transport chain and Komplex V.

My mouth mucus skin is often rough when this is better, i feel a little better.
When I take the tiniest dose of a B-Komplex out of the cap my body immediately responds an it feels like he‘s trying to ramp up cellular metabolism, but the flu-like feeling becomes unbearable and even the following days my legs and my mouth (inside) feel like cramping.
It‘s like my body starts to produce and then there‘s a block. But even after 6 years i could not lift it. Everything got worse (leg cramping). Things that worked in the past like Glutathion or Alpha lipoic acid or antibiotics or whatever don‘t work. I react to everything. What the hell is ist an did anyone find a solution? It feels like lifting what hinders me taking a full multi B vitamin complex would solve my worst problems.