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I'm so sorry your son is having these issues.
I wonder if by any chance he could do some small bits of drawing? If you encouraged him to just do that a couple minutes daily, maybe that would give some insight. At first, of course, it might not tell you much but if he got comfortable doing it, it could really change over time. Just a thought.
The basic first things which you may have already considered a lot would be: Is there any chance that something has changed in his environment, diet, supplements, or medications prior to the change? Maybe a quite a bit prior? Or anything traumatic or upsetting that didn't cause depression but caused a sort of fear/trauma withdrawal.
I wonder if by any chance he could do some small bits of drawing? If you encouraged him to just do that a couple minutes daily, maybe that would give some insight. At first, of course, it might not tell you much but if he got comfortable doing it, it could really change over time. Just a thought.
The basic first things which you may have already considered a lot would be: Is there any chance that something has changed in his environment, diet, supplements, or medications prior to the change? Maybe a quite a bit prior? Or anything traumatic or upsetting that didn't cause depression but caused a sort of fear/trauma withdrawal.