Fibromyalgia pain real says new study


Contaminated Cell Line 'RustyJ'
Mackay, Aust
Not imagining it.

New study provides insight into how pain occurs
Washington , Fri, 30 Jul 2010ANI

Washington, July 30 (ANI): The first direct evidence of linkage between elevated intrinsic (resting-state) brain connectivity and spontaneous pain intensity in patients with fibromyalgia (FM) has been provided by a recent study.

The study by researchers at Massachusetts General Hospital and University of Michigan shows an interaction of multiple brain networks, offering greater understanding of how pain arises.

The National Institute of Arthritis and Musculoskeletal and Skin Diseases estimates that FM affects 5 million American 18 years of age or older, occurring more often in women (80 percent-90 percent).

In the current study, Vitaly Napadow, Ph.D. and colleagues enrolled 36 female subjects -18 FM patients and 18 healthy control subjects with a mean age of 38.9 and 36.1 years of age, respectively.

FM study subjects had a disease-duration of at least 1 year, self-reported pain for more than 50 percent of each day, and were willing to limit introduction of new medications or treatment strategies to control FM symptoms.

Prior to undergoing the MRI scan, participants were asked to rate the intensity of their FM pain on a scale of 0, where 0 is equivalent to "no pain present" and 10 is equivalent to "the worst pain they could imagine." The pain scores ranged widely, from 0 to 8.1.

"Our results clearly show that individuals with FM have greater connectivity between multiple brain networks and the insular cortex, which is a brain region previously linked with evoked pain processing and hyperexcitability in FM," said Dr. Napadow.

The research team found that patients with FM had greater intrinsic connectivity within the right EAN, and between the DMN and the insular cortex-a brain region linked to evoked pain processing.

"In patients with FM, our findings strongly implicate the insular cortex as being a key node in the elevated intrinsic connectivity," added Dr. Napadow.

"Patients demonstrated greater DMN connectivity to the left anterior, middle, and posterior insula."

In the right EAN, FM patients demonstrated greater intra-network connectivity within the right intraparietal sulcus (iPS). Researchers found no differences between the FM and healthy control groups for the left EAN or the MVN.

Details of the study appear online and in the August issue of Arthritis and Rheumatism, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology.(ANI)


Senior Member
Think I'll slip a copy of this in my handbag for when my doctor says 'did you know some people don't believe in this?'


Thanks for this RustyJ

so it's all in my head is it (hee hee)

I found some links - the article is from ANI (Asian News International/
originally and then picked up from there

and the press release from Wiley Press for the Arthritis & Rheumatism Journal on the study:

Resting Brain Activity Associated with Spontaneous Fibromyalgia Pain
Interaction of Multiple Brain Networks Provides Insight into How Pain Occurs

is here


Senior Member
Olympic Peninsula, Washington
Anything to make me stop growling at the screen when the Lyrica commercial comes on and the voiceover guy blabs that garbage about how FM is thought to be a result of overactive nerves or some such nonsense! Yay!