Current statuc check
"According to sources that can't be named right now" the current state of play looks something like this. . .
There are 5 negitive studies that do not correlate CFS and XMRV
1- Erlwein O, Kaye S, McClure MO, Weber J, Wills G, Collier D, Wessely S, Cleare A.
PLoS One. 2010 Jan 6 Total 0 CFS 0 HC
2-Groom HC, Boucherit VC, Makinson K, Randal E, Baptista S, Hagan S, Gow JW, Mattes FM, Breuer J, Kerr JR, Stoye JP, Bishop KN.
Retrovirology. 2010 Feb 15 Total 1 CFS and 4 HC
3-van Kuppeveld FJ, de Jong AS, Lanke KH, Verhaegh GW, Melchers WJ, Swanink CM, Bleijenberg G, Netea MG, Galama JM, van der Meer JW.
BMJ. 2010 Feb 25 Total 0 CFS and 0 HC *
(*caveat is that WPI found 2 XMRV positive from 10 samples sent to them by Van Kupperveld which was omitted from the original paper)
4-The Hubner study which has not been published at this time but which was leaked by Dr. Hubner and is reportedly a zero/zero study
5- The CDC paper which was completed early on and is reportedly a zero/zero study as well
Now the THREE positive studies are. .
1-Lombardi VC, Ruscetti FW, Das Gupta J, Pfost MA, Hagen KS, Peterson DL, Ruscetti SK, Bagni RK, Petrow-Sadowski C, Gold B, Dean M, Silverman RH, Mikovits JA.
Science. 2009 Oct 23;326(5952):585-9. Epub 2009 Oct 8. Total 68 CFS 8 HC **
(There are two additional studies often referenced by Dr. Mikovitz in talks reporting numbers in FAMILIAL illnesses including CFS families with members who have Autisum, MS, and Fibromyalgia this paper has been ready for publication and passed peer review, according to Dr. Mikovitz since February and a second study that uses the same Science cohort that reports a 98% incidence of XMRV in CFS patients that has also been review and ready to be publish since February)
2- The second study was reportedly completed by the FDA in April and rumors have the numbers anywhere from 80% CFS to 99% CFS and HC from 3% to 10%. Until this study is published we just don't know. But per the source that can not be named the FDA study is a unique stand alone study not associated with the NIH study. Totals unknown
3-Which brings us to the third study that is also being held up and that's the NIH study. Again rumors abound and I've read "reliable" reports of 80 to 95% in CFS patients and 3 to 7% of HC*** (This number seems to come from the slide given at the IPFA/PEI 17th Workshop on 'Surveillance and screening of Blood Borne Pathogens' in Zagreb. The slide states that XMRV and MLV's are present in the blood supply at 3 to 7% so those numbers are ambiguous at best) Totals unknown
The fact that there are THREE positive studies was stated in the videos, for some reason people keep making the FDA/NIH into one study. Incorrect.
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In addition to this the Dr.'s Light study on Interferon and PEM which added an XMRV study to the end of it has never been published and we know from anecdotal evidence that an additional study was executed by the Dr.'s Light in April (is that correct CBS?) of this year.
And the Glaxo-Smith-Klien study that was started end of March or 1st of April.
Also data presented at the Prague CROI has yet to surface as well as the Cold Harbor Springs Conference which is referenced in our non-referenceable reference. (big grins)
Another extremely important point gleaned from our unnamed sources is why the various papers have come up negative. If you read the negative papers that are published you will find that all three used the ENV portion of the XMRV virus rather than the GAG portion. Turns out and this is a very important piece of information that the ENV is the area of change. We also know that being off just a little will cause zero results. We won't know for a fact until the Huebner and CDC studies are published that they in fact looked at ENV instead of GAG but most likely this is the case.
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In addition to this information it's known that recruiting has started in the area of research to look at the disease mechanism for XMRV in Chronic Fatigue Syndrome. This is several steps ahead from just "linking" the virus in a Koch's Postulate kinda way to the illness. This is "hey we're pretty sure we got the what now we need to look for the how" area of study.
The actual studies themselves aren't really noteworthy at this time because they are shot's in the dark more or less. There are hundreds of MLV mouse studies that have been preformed over the last four decades. Researchers are currently trying to match up possible models that have been studied to what's known about the CFS disease model today. It will be a while before we get anything in that are nailed down.