Ethyl 3-Hydroxyhexanoate (EHX) Is Antiviral For Coxsackievirus B In Vivo

[Hip]

My wife got it the day before and 24 hours later everything was fine again. Which almost certainly points to Noro.

The enterovirus I caught (coxsackievirus B4) which triggered my ME/CFS caused similar gastrointestinal symptoms lasting for 24 hours in many who caught it.

In many people my CVB4 viral infection would start as a gastrointestinal upset lasting for about 24 hours, in others it might begin as a a herpangina sore throat.

If you look at these acute symptoms of enterovirus on MEpedia, you see that it can produce a range of symptoms.

Norovirus has never been connected to ME/CFS in any study, and ME/CFS doctors do not test for this.

 

[Dude]

After reading the article, you might be right. They are actually quite similar in symptoms. Never thought about that. I wonder if sofosbuvir could help us as it seems to be effective against several rna viruses (dengue, chikingunya)?

 

[Hip]

I wonder if sofosbuvir could help us as it seems to be effective against several rna viruses (dengue, chikingunya)?

!0 years ago it was hoped that sofosbuvir would treat enterovirus, but an in vitro test found it unfortunately has no effect against coxsackievirus B. This comment is where the negative test result was posted on this forum.


Though the chronic non-cytolytic enterovirus infections found in ME/CFS are different to the acute enterovirus infections normally used in viral testing in vitro, so it's possible that sofosbuvir could still have some effects against chronic enterovirus.

Have you tried oxymatrine? This is Dr Chia's usual treatment for enterovirus ME/CFS, and it works for a small subset of patients.

 

[Dude]

I tried to source the original from chia. But i couldnt find a seller in Europe. It seems its only available in the states. I then orderd something similiar, forgot the name. A tiger was on the package. But i never received it.
What about the Pleconaril thats mentioned in the Article?

 

[Hip]

What about the Pleconaril thats mentioned in the Article?

That drug unfortunately never reached the market.

 

[Charles555nc]

That drug unfortunately never reached the market.

Any permanent improvement on this EHX experiment for you, Hip?

 

[Hip]

Any permanent improvement on this EHX experiment for you, Hip?

I could not really test EHX, as I found it caused some mental side effects detailed in this post, so had to stop taking it.

 

[godlovesatrier]

Did anyone else try it Hip?

 

[Dude]

Did anyone else try it Hip?

Yes #16 in this thread.

 

[Dude]

That drug unfortunately never reached the market.

https://www.biosynth.com/p/FP27098/153168-05-9-pleconaril

It is available, but only for research purposes and probably toxic.

An interesting article by Polybio on the enterovirus thesis.

 

[Hip]

https://www.biosynth.com/p/FP27098/153168-05-9-pleconaril

It is available, but only for research purposes and probably toxic.

Interesting, but unfortunately the amounts of pleconaril being sold are too small for human dosing, which requires 400 mg three times daily.

This is from Dr Chia's study:

Four patients with CFS and either persistently raised antibody titres for CVB or echoviruses and/or positive enteroviral RNA of the peripheral blood leucocytes were treated with Pleconaril, an anti-capsid agent specific for uncoating of enterovirus and rhinovirus, obtained through a compassionate use protocol of Viropharma Inc, Exton, Pennsylvania, USA.

Three patients had no symptomatic improvement while on or after one week of drug treatment, at a dose of 400 mg three times a day, and there was no change of antibody titre after the treatment.

One patient had a moderate symptomatic improvement while taking Pleconaril 200 mg three times a day for one month, along with a fourfold decrease of antibody titres for CVB4 and echoviruses 7 and 11. However, she relapsed about one month later, and did not respond to a further month of treatment. As of March 2004, the oral form of Pleconaril is no longer available for investigational use.