EPA/IPE and pure EPA brands

[godlovesatrier]

There are a few threads on this but I want to draw peoples attention to Long covid pharmas substack on IPE. If you can't get IPE on prescription in america or elsewhere then EPA supps are second best.

Long covid pharma went to the trouble of researching them for us and checking toxicology. She's a pharmacist if you're wondering.

https://pharmd.substack.com/p/high-dose-epa-for-long-covid-and

So whilst IPE is the best thing to get on prescription, a good EPA supp is your second best.

Any product will not do, the product has to have high levels of pure EPA, with next to no DHA to stand a chance of even working. You also need to take 2 to 4g a day to get anywhere near the IPE dosage.

DHA vs EPA benefits:

Products

I tried the nordic brand but it had lemon fragrance in it and gave me unplesant heartburn, also I didn't notice any real improvement.

I've also taken vegepa and noticed zero benefit - literally nothing.

Today I took https://www.amazon.co.uk/dp/B007TUK2IE?psc=1&ref=ppx_yo2ov_dt_b_product_details PharmEPA. I took 4 caps which equals 2g and I had enough energy to go to the shop, wash up, make lunches for the week and write this post. Still with some energy to spare. Quite a huge benefit to be honest I was surprised. I've taken omega 3 for 6 years but long covid pharma's analysis got me intrigued in pure EPA with very little to no DHA.

Be interesting to see what happens with other areas like cognition. Normally if I did as much as I did today I'd get dizzy and feel a bit disorientated and need to sit down.

So thought I'd share these brands and the PharmEPA expeirnece.

 

[keepswimming]

Thanks for this post. I have been looking into EPA myself and just bought these to try
https://uk.iherb.com/pr/omegavia-epa-500-pure-epa-omega-3-120-capsules/94909
If I feel a benefit I will let you know!

 

[godlovesatrier]

Nice. Good to see your still with us btw. Now I've left twitter I guess I'm inclined to post more we will see.

That product looks good! Four of those a day also far more cost effective. Just be careful of toxicity. She checked for that too. A lot of products haven't got it. But this one looks a million times more cost effective.

 

[keepswimming]

Thank you! Yes I'm still here haha, I just do more reading than posting!

Thanks, I saw the Pharmaepa and it did look excellent, but this one was more cost effective... I researched the company and they seem to be a decent quality too. I will keep you posted

 

[godlovesatrier]

Yeah let us know. These products aren't cheap I just wish iherb postage wasn't so slow. Good luck!

 

[hapl808]

I've also taken vegepa and noticed zero benefit - literally nothing.

Today I took https://www.amazon.co.uk/dp/B007TUK2IE?psc=1&ref=ppx_yo2ov_dt_b_product_details PharmEPA. I took 4 caps which equals 2g and I had enough energy to go to the shop, wash up, make lunches for the week and write this post. Still with some energy to spare. Quite a huge benefit to be honest I was surprised. I've taken omega 3 for 6 years but long covid pharma's analysis got me intrigued in pure EPA with very little to no DHA.

Interesting that VegEPA did nothing but PharmEPA was helpful. Same brand but different ratio. I think I've had the VegEPA but never the PharmEPA one - maybe I'll try it.

 

[almost]

Very interesting. Has anyone tried Orthomega Select EPA? Pricey, yes, however, has an excellent ratio.

Edit:
I see the PharmaEPA Restore has very little DHA, so this ratio would be much, much higher, so probably the best to trial.
https://www.amazon.com/Pharmepa-Abs...id=1692738125&sprefix=pharmepa,aps,150&sr=8-1

 

[almost]

A caution from the linked article to keep in mind:

CAUTIONS:

Atrial fibrillation

In the REDUCE-IT trial, a significantly larger percentage of patients in the IPE group vs placebo group were hospitalized for atrial fibrillation or flutter (3.1% vs. 2.1%, P=0.004). Overall, 5.3% (IPE) vs 3.9% (placebo) experienced AFib or AFlutter. A meta-analysis of seven omega-3 fatty acid studies found that heightened risk of AFib is not limited to just IPE, but any omega-3 fatty acids. If you notice a worsening of heart palpitations, fatigue and/or shortness of breath, contact your doctor to be evaluated. Those with a history of AFib or atrial flutter should speak with their doctor before starting EPA ≥ 1 g daily.

A 5% chance of experiencing this is not great, but also not zero or insignificant. Given my history, this gives me pause.

 

[Judee]

Here is another thread where Hip is talking about EPA only supplements. https://forums.phoenixrising.me/threads/vegepa-omega-3-6-good-idea-or-not.10303/page-2#post-728746

I wonder if anyone back then tried this and got benefit?

 

[hapl808]

A 5% chance of experiencing this is not great, but also not zero or insignificant. Given my history, this gives me pause.

Definitely a concern, but keep in mind it's 5.3% vs 3.9% in the placebo group. That's a significant increase in risk, but it's not just 5% overall against 0%.

 

[almost]

keep in mind it's 5.3% vs 3.9% in the placebo group

Correct. I quoted the non-placebo since that's what would apply if I trialed this.

 

[linusbert]

A caution from the linked article to keep in mind:


A 5% chance of experiencing this is not great, but also not zero or insignificant. Given my history, this gives me pause.

i actually was expecting this.
and i dont believe it to be anything related to omega3 at all.
i bet that people eating fatty fish rich in those will not have this problem. and maybe unprocessed cod liver oil wont neither (if its not oxidized/rancid).

those re esterified omega3's are so insanely processed that alone with this fact i wouldnt touch them. (i tried vegepa/pharmagepa anyways, didnt work out, hurt burn and potential allergic to some ingredient)
the processing they do with those oils is insane. some let their oil ferment in a tank for long time at high temperatures... now how would that affect oxidation i wonder.
everytime i try a new fish oil product its rancid. those fish burbs i shouldnt have i have them with almost every product. thats why they put lemone flavour into those to mask the foul taste of rancid fish.
no one gets this from fresh fish.

so the bad heart effects are probably a result of consuming oxidized/rancid oils over long time.

also oils arent just rancid or not - like 1 or 0. its always a spectrum. the TOTOX value shows this. a oil which is only oxidized to 5-10 % (TOTOX 5-10) is considered a good oil. when they measured the TOTOX value was before they put the product in shelves for month or years. nobody knows the real oxidation when the food gets consumed.

the supplement industry are lyers and scammers. caution is highly advised especially with oxidized fats.

also omega3s increase the demand of VITAMIN E no matter if rancid or not. so if one has much omega3 they shall also have much vitamin E. (of course the E mustnt be rancid either...)
those sideeffects could also be sign of vitamin E deficiency.

at this point, my only source for omega3's are raw eggyolks. those i can consume fresh.

 

[SWAlexander]

Hi everybody.
My skeletal muscle weakness seems to progress and my PCP recommended omega 3 (a product called MAP), without considering that I have elevated Phytanic acid. I´m a little hesitant
What is your opinion?
Thanks.
These are the indigence.

 

[almost]

Thanks @linusbert , very cogent argument.

 

[linusbert]

Hi everybody.
My skeletal muscle weakness seems to progress and my PCP recommended omega 3 (a product called MAP), without considering that I have elevated Phytanic acid. I´m a little hesitant
What is your opinion?
Thanks.
These are the indigence.
View attachment 52369

i guess the usual muscle protectors like Creatine, Carnitine, Q10, Ribose you already tried?

 

[Tammy]

My skeletal muscle weakness seems to progress and my PCP recommended omega 3 (a product called MAP),

Not sure if I'm reading this right? MAP doesn't look like an omega 3 supplement? It's a combo of amino acids some of which are the branch chain amino acids.

 

[linusbert]

i just stumbled upon this and wanted to share, its not directly related with omega3 , but they found that daily fish/codliveroil consumption or none at all are connected with increased risk for asthma.
so its U shaped, a lot of it and none increase the risk.

https://pubmed.ncbi.nlm.nih.gov/17877766/

 

[SWAlexander]

i just stumbled upon this and wanted to share, its not directly related with omega3 , but they found that daily fish/codliveroil consumption or none at all are connected with increased risk for asthma.
so its U shaped, a lot of it and none increase the risk.

That's the key sentence: "Subjects who never ate fish in childhood were at an increased risk for asthma. Both indicate a possible threshold effect of fish on asthma."
We rarely eat fish, maybe once a month and if, then only trout in spring.
thanks for the link.

MAP doesn't look like an omega 3 supplement

I checked it too. This was the reason for my hesitancy. I took it for two days and I had to stop because of shortness of breath.
We should not blindly trust everything a doctor recommends.

 

[SWAlexander]

Q10, Ribose you already tried?

I have tried Q10 and had to stop. Elevated heart rate and tingling all over, especially at night.

 

[Judee]

my only source for omega3's are raw eggyolks. those i can consume fresh.

I can't do eggs...they make me so sick...would canned salmon also have rancid oils, do you think? I've been craving fish lately and had some of that available.