Encapsulating leaky gut repair supplements in capsules to target the colon (where bacteria & LPS live) rather than the sterile small intestine

Hip

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@Hip : really nice idea with the colon Capsule! Did you Track this Any further?
No, I did not take the capsule idea any further as yet.

But as an experiment I tried using enema-type equipment to inject glutamine (dose of 2 heaped teaspoons) plus probiotics into my colon. But each time I did this, I became more tired, depressed and more emotionally frail soon afterwards.

There was also quite a bit of gurgling in the intestines a couple of hours after administering the glutamine and probiotics into my colon. When I just tried administering the probiotics alone, I did not get any of these side effects, suggesting it was the glutamine that caused all these side effects.

Yet when I take high doses of glutamine orally, I don't get any such problems.

After a few days of performing such colon administration of glutamine plus probiotics, I stopped because of the side effects.



Since glutamine is supposed to help repair leaky gut, I am not sure why I got these side effects.

It's possible that if I persevered for a bit longer, might have got over these side effects (which might have been some sort of Herx reaction), and perhaps then glutamine might have started providing benefits by perhaps healing leaky gut. Glutamine is considered the best supplement for repairing leaky gut.

(I have not actually been tested for leaky gut, but I have IBS-D, and leaky gut is common in this condition).
 

Mick

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Then: there it is in the toilet, not dissolved at all.
Oh my, TMI. Ok, I'm kidding here.

The question is: why wasn't it dissolved? Probably because your stomach environment is not acidic enough. If it is so, then you can do something about it.

Alternatively: the passage of food through the gut is too fast (ie. diarrhea). This one is much more difficult to manage...
 

hb8847

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But as an experiment I tried using enema-type equipment to inject glutamine (dose of 2 heaped teaspoons) plus probiotics into my colon. But each time I did this, I became more tired, depressed and more emotionally frail soon afterwards.

There was also quite a bit of gurgling in the intestines a couple of hours after administering the glutamine and probiotics into my colon. When I just tried administering the probiotics alone, I did not get any of these side effects, suggesting it was the glutamine that caused all these side effects.
Wow, this is a method I've not heard of for glutamine.

For what it's worth (and I've mentioned this elsewhere) I've had negative reactions to oral glutamine in the past, and I'm pretty sure it wasn't Herx related. My feeling is it's a pretty powerful supplement, if I understand correctly it can contribute to lots of biological processes (eg methylation and the synthesis of glutathione) which if you're sensitive can trigger a strong reaction, as it did in my case.

Elsewhere I'd probably be a tad reluctant personally about doing an enema of something that isn't generally built to survive passage to the colon - perhaps this was the reason for your reaction, the body didn't appreciate the presence of something where it shouldn't be? Just a thought, obviously it's up to you what experiments you try, God knows people have tried a lot worse.

Have you read anywhere that leaky gut of the large intestine (colon) is a large concern? I've always heard it referred to as a small intestine issue and generally in conjunction with SIBO. I guess there's no reason why you shouldn't also get it in the colon just I've not seen it mentioned anywhere.
 

Hip

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Have you read anywhere that leaky gut of the large intestine (colon) is a large concern? I've always heard it referred to as a small intestine issue and generally in conjunction with SIBO. I guess there's no reason why you shouldn't also get it in the colon just I've not seen it mentioned anywhere.
I know that different leaky gut tests will measure the level of leakiness in different parts of the digestive tract.

The lactulose/mannitol test only measures leakiness in the small intestine, and cannot detect leakiness in the colon. Whereas the polyethylene glycol test checks your intestines as a whole for leakiness (the small intestine and the colon). If you took both tests, you would be able to work out exactly where your leaky gut is located. I have not taken any leaky gut tests, but I should really.

I suspect that bacterial toxins leaking from either the small intestine (in the case of SIBO) or the large intestine (colon) might potentially be an issue, and if you wanted to address this issue, I guess you would want to target the part of the intestines that was leaking.


Here are a couple of papers indicating that glutamine enemas have a protective, healing effect in the colon:

L-glutamine enemas attenuate mucosal injury in experimental colitis
Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis
 

Thomas

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Wouldn’t other leaky gut herbs like slippery elm bark, marshmallow root, licorice root etc reach the colon? They contain fiber which tends to reach the large intestine. With Glutamate being an amino acid I can see why it wouldn’t reach the large intestine. I have a leaky gut repair formula from Dr. Amy Myers brand which contains all the above herbs and glutamate and I think a few other things. Orally they never did much for my life long IBS (which for me is more emotionally devastating at times than my ME) so I may go the enema route. My gut symptoms have been really bothersome lately and nothing really works anymore.

Whenever I administer an enema I use disposable Fleet enemas. It becomes costly but it saves me a lot of energy dealing with and sanitizing reusable enema kits. Btw I find Fleet enemas as effective for my IBS D as I do for my IBS C (I have IBS M - mixed).
 

Hip

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Wouldn’t other leaky gut herbs like slippery elm bark, marshmallow root, licorice root etc reach the colon? They contain fiber which tends to reach the large intestine. With Glutamate being an amino acid I can see why it wouldn’t reach the large intestine.
I guess the fiber content would reach the colon. But maybe the fiber is not the part that helps leaky gut?

According to this study, "glutamine is presently the best known compound for reducing IP [intestinal permeability]". And I have heard naturopaths state the same thing. So that's why I was focusing on glutamine.

There is large list of leaky gut supplements in this post.
 

Thomas

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I guess the fiber content would reach the colon. But maybe the fiber is not the part that helps leaky gut?

According to this study, "glutamine is presently the best known compound for reducing IP [intestinal permeability]". And I have heard naturopaths state the same thing. So that's why I was focusing on glutamine.

There is large list of leaky gut supplements in this post.
Yes good point I guess it’s not a guarantee that the healing properties of these herbs would successfully reach the colon.
ah thanks for the reminder for NAG from your list. I was having a little success with that supplement a few years ago. I didn’t get the anxiolytic effect as you did but it did feel like it was helping with my gut lining.
 

hb8847

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So my understanding of intestinal bacteria was that when good bacteria is introduced (in the form of probiotics) it makes its way to the colon, and does not remain in the small gut.

Indeed this was what I've been told from a few doctors, including a Gastroenterologist specialising in gut bacterial dysbiosis.

His protocol for fixing said dysbiosis includes (1) targeted antibiotics and (2) a water based probiotic called Symprove which has rave ratings over here in the UK. He specified it was important to start both at the same time and claimed he had treated several people in his clinic with gut disorders with this very protocol.

I asked about whether I should be worried about the probiotic adding to my SIBO if not all the small intestine bacteria had been wiped out by the antibiotics, he said no as the Symprove probiotic bacteria wouldn't settle in the small intestine, it would go down to the large intestine, and in fact in doing so it would also help to displace any remaining bacteria residing in the small intestine.
 

Thomas

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So my understanding of intestinal bacteria was that when good bacteria is introduced (in the form of probiotics) it makes its way to the colon, and does not remain in the small gut.

Indeed this was what I've been told from a few doctors, including a Gastroenterologist specialising in gut bacterial dysbiosis.

His protocol for fixing said dysbiosis includes (1) targeted antibiotics and (2) a water based probiotic called Symprove which has rave ratings over here in the UK. He specified it was important to start both at the same time and claimed he had treated several people in his clinic with gut disorders with this very protocol.

I asked about whether I should be worried about the probiotic adding to my SIBO if not all the small intestine bacteria had been wiped out by the antibiotics, he said no as the Symprove probiotic bacteria wouldn't settle in the small intestine, it would go down to the large intestine, and in fact in doing so it would also help to displace any remaining bacteria residing in the small intestine.
What antibiotic does he use and for how long?
 

Hip

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Hi @Hip, have you explored the glutamine administration any further? Or retrial the colon tube? Looking into trying to fix my gut
Only on a very short term basis, like for a few days. This is because I tend to feel more tired and more depressed when I infuse 2 heaped teaspoons of glutamine into my colon. I am not sure why that is, because I do not get these side effects when I take the same glutamine dose orally.

I guess it could be due to some bacterial die-off reaction in the colon (since glutamine boosts mucosal immunity, as well as fixing leaky gut). It may be that if I persist, the die-off side effects will disappear, and benefits will later manifest.
 
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Only on a very short term basis, like for a few days. This is because I tend to feel more tired and more depressed when I infuse 2 heaped teaspoons of glutamine into my colon. I am not sure why that is, because I do not get these side effects when I take the same glutamine dose orally.

I guess it could be due to some bacterial die-off reaction in the colon (since glutamine boosts mucosal immunity, as well as fixing leaky gut). It may be that if I persist, the die-off side effects will disappear, and benefits will later manifest.
Yeah, very strange. Please share if you do end up doing it for a longer period! Thanks