elevated Parvovirus B19 antibodies

[tedstark]

Can anyone remark on the significance of low b19 IGM levels and very high b19 IGG levels? Worth pursuing, or is this standard for someone with a past infection?

 

[Judee]

I'm not sure this answers your question at all but many of us here do seem to have IgM deficiency and it was speculated to me by a doctor that testing for recent infections using IgM (at least) for people with deficiency might not be accurate. I did email a lab and one of their technicians confirmed this as well.

However, I do think a lot of the ME doctors do use high IgG titers as an indication of possible viral reactivation.

Hope someone answers that better for you.

 

[Hip]

Dr John Chia diagnoses active parvo infection when the PCR test is positive, or when there are high IgM antibodies. Ref: here

 

[Judee]

Also Shanti1 mentioned that the doctor she saw in Florida tests for Parvo, I believe. He also has a book out that I got from Hoopladigital as a temporary loan through my library system. I haven't read that far yet...only can manage a small amount of pages at a time but if you were interested maybe you could see if you can access the book as well.

Anyway, here is the thread where she talked about him. https://forums.phoenixrising.me/thr...-the-us-still-treat-me-with-antivirals.88113/

 

[Shanti1]

Also Shanti1 mentioned that the doctor she saw in Florida tests for Parvo, I believe. He also has a book out that I got from Hoopladigital as a temporary loan through my library system.

I just looked in my copy of the book. Dr. Dantini considers anything 4x or higher above the top value of the reference range to be a potential positive for IgG for parvovirus.

 

[Pyrrhus]

By the way, parvovirus B19 is one of the few persistent infections that can actually be found in blood, since it primarily infects blood cells.

So a PCR blood test may actually be helpful in diagnosing parvovirus B19, unlike with other persistent infections.

Treating it, however, is much harder...

 

[Shanti1]

@Pyrrhus Do you know if one would expect to see some hints, like low RBC count or joint pain if someone had parvo as a smoldering infection contributing to their ME?

 

[Pyrrhus]

@Pyrrhus Do you know if one would expect to see some hints, like low RBC count or joint pain if someone had parvo as a smoldering infection contributing to their ME?

Off-hand I don't know, but that's a good question.

I only know that a persistent parvovirus B19 infection can come with severe disabling fatigue, but I don't think it comes with PEM.