Dr. Pridgen's 9 different cocktail mix patents & research under Dr. Carol Duffy name

[heapsreal]

Antivirals could be reducing inflammation by reduce viral load. They should run a study with antivirals on non cfs non viral people to see what happens with inflammation??

 

[Hip]

Hah

I didn't intend it to come off as suspicious. Just curious.

I am definitely going to be trying this Pridgen protocol soon, especially since the last time I was tested (several years ago), I had high titers to HSV-1, indicating reactivation (as I have had HSV-1 since childhood).

However, I don't have fibromyalgia, and just how well the Pridgen protocol translates to ME/CFS remains to be seen.

 

[Hip]

Nice work HIp. Just wondering, though, in light of Dr Montoyas recent statement that Valcyte is antiinflammatory, if the effect Pridgen is getting isn't really through inhibiting inflammation rather than antiviral.

Perhaps the anti-inflammatory effects of COX-2 inhibitors might conceivably provide some symptomatic relief to fibromyalgia patients, and even have some benefits for disease pathogenesis.

However, from what I have read, it seems that the COX-2 pathways plays an important role in viral replication for a number of viruses.

This study mentions that:

Infections by several viruses, including many herpesviruses, such as HSV, human cytomegalovirus, Epstein-Barr virus, and murine gammaherpesvirus 54, have been reported to alter COX-2 expression. In fact, rhesus cytomegalovirus even encodes a COX-2 homolog in its genome, emphasizing the importance of this enzyme.

It is particularly telling that rhesus cytomegalovirus actually possesses genes which enable it to make its own fake (homolog) COX-2. This shows that it is very important for this virus to have high levels of COX-2 for its survival.



Another interesting thing which that study found is that inhibition of either COX-1 or COX-2 caused a moderate inhibition of pseudorabies virus growth (25-fold to 30-fold), but when both COX-1 and COX-2 were inhibited simultaneously, either with a nonspecific COX inhibitor or with a combination of specific COX-1 and COX-2 inhibitors, pseudorabies virus yields were dramatically reduced (greater than a 200,000-fold reduction).

Note that the pseudorabies virus which the researchers studied is similar to herpes simplex.

 

[Rrrr]

Perhaps the anti-inflammatory effects of COX-2 inhibitors might conceivably provide some symptomatic relief to fibromyalgia patients, and even have some benefits for disease pathogenesis.

However, from what I have read, it seems that the COX-2 pathways plays an important role in viral replication for a number of viruses.

This study mentions that:


It is particularly telling that rhesus cytomegalovirus actually possesses genes which enable it to make its own fake (homolog) COX-2. This shows that it is very important for this virus to have high levels of COX-2 for its survival.



Another interesting thing which that study found is that inhibition of either COX-1 or COX-2 caused a moderate inhibition of pseudorabies virus growth (25-fold to 30-fold), but when both COX-1 and COX-2 were inhibited simultaneously, either with a nonspecific COX inhibitor or with a combination of specific COX-1 and COX-2 inhibitors, pseudorabies virus yields were dramatically reduced (greater than a 200,000-fold reduction).

Note that the pseudorabies virus which the researchers studied is similar to herpes simplex.

to your point above: if the study says that there has to be both cox 1 and cox 2 inhibiting going on for it to be effective, then that would be a reason that the natural cox 2 inhibitors would not suffice -- because they don't inhibit both cox 1 and cox 2.

someone told me that willow was a cox 1 inhibitor. but i have not double checked that.

 

[Rrrr]

Pridgen on TV
http://wvuatv.com/content/fibromyalgia-treatment

 

[Hip]

to your point above: if the study says that there has to be both cox 1 and cox 2 inhibiting going on for it to be effective, then that would be a reason that the natural cox 2 inhibitors would not suffice -- because they don't inhibit both cox 1 and cox 2.

someone told me that willow was a cox 1 inhibitor. but i have not double checked that.

I wouldn't have thought that is the reason, because the drugs used by Pridgen (at least in his patent) are more COX-2 inhibitors than COX-1 inhibitors. It's more likely that the natural COX-2 inhibitors are too weak compared to the drug inhibitors.

According to their Wikipedia articles, the drugs celecoxib, diclofenac and meloxicam primary inhibit COX-2, with less inhibition of COX-1.

Propolis I believe is also primarily a COX-2 inhibitor, with little inhibition of COX-1 (according to this study).

Aspirin is a good COX-1 inhibitor, but has very little COX-2 inhibition. Ibuprofen is both a COX-1 and COX-2 inhibitor.

 

[Jon_Tradicionali]

I am definitely going to be trying this Pridgen protocol soon, especially since the last time I was tested (several years ago), I had high titers to HSV-1, indicating reactivation (I have had HSV-1 since childhood).

However, I don't have fibromyalgia, and just how well the Pridgen protocol translates to ME/CFS remains to be seen.

Phase II has a few CFS patients taking part also.

 

[maryb]

I am definitely going to be trying this Pridgen protocol soon, especially since the last time I was tested (several years ago), I had high titers to HSV-1, indicating reactivation (as I have had HSV-1 since childhood).

However, I don't have fibromyalgia, and just how well the Pridgen protocol translates to ME/CFS remains to be seen.

Me too @Hip I have FM as well as high HSV1 &2 titres. Hurry up Pridgen, we want the formula.

 

[Jon_Tradicionali]

Me too @Hip I have FM as well as high HSV1 &2 titres. Hurry up Pridgen, we want the formula.

I'd like your comment 10 times if I could!

 

[lartista]

Considering you've researched the protocol and COX2, may I ask why YOU have yet to try it?

If it works, it would achieve remission and I'm sure you'd be thrilled with that result.

I did take VALTREX which is Valacyclovir and it worked great within 6 weeks. I was on Klimas' three cocktails (LDN, VALTREX, IMUNOVIR) but do to a 2nd heart surgery in April 2013 I was forced to get off all drugs 2 months before the surgery and had to stay off 2 months after.

I choose to stay off all three to see how far I could go before relapse as Klimas told me I would relapse, it took one year and I had a MAJOR RELAPSE which I am still in now... I was then diagnosed with CVID around July 2013 and they started IV IGG treatments... it seemed to be holding me... But by January 2014 came the full relapse.

My appointment with Klimas was Feb 28, 2014 and I had to follow what she says as she is the expert and doctor... So I have been reloading LDN - am in my second month at 3 mgs daily and am reloading Imunovir which I am starting week three. I spoke to her again this week MArch 3, 2014 as my POTS kept me vertical for 3 months now. I asked can I not please start the VALTREX again? She said no... one drug at a time Francesca... I want your third drug to be IGG subcutanous...

I said this that a conflict or the same as Valtrex... she said it is different but since you have CVID too, we must get the IGG in next. "Francesca, I AM WORKING ON IT BE PATIENT!" So it is her hopes that these two plus the IGG will get me stable... then once I am there... I will see what she says.... I hope that helps with why I am not doing that protocol... I also asked for a sleep aid and Klimas said WAIT FRANCESCA... give these drugs a chance...

 

[Jon_Tradicionali]

I did take VALTREX which is Valacyclovir and it worked great within 6 weeks. I was on Klimas' three cocktails (LDN, VALTREX, IMUNOVIR) but do to a 2nd heart surgery in April 2013 I was forced to get off all drugs 2 months before the surgery and had to stay off 2 months after. I choose to stay off all three to see how far I could go before relapse as Klimas told me I would relapse, it took one year and I had a MAJOR RELAPSE which I am still in now... I was then diagnosed with CVID around July 2013 and they started IV IGG treatments... it seemed to be holding me... But by January 2014 came the full relapse. My appointment with Klimas was Feb 28, 2014 and I had to follow what she says as she is the expert and doctor... So I have been reloading LDN - am in my second month at 3 mgs daily and am reloading Imunovir which I am starting week three. I spoke to her again this week MArch 3, 2014 as my POTS kept me vertical for 3 months now. I asked can I not please start the VALTREX again? She said no... one drug at a time Francesca... I want your third drug to be IGG subcutanous... I said this that a conflict or the same as Valtrex... she said it is different but since you have CVID too, we must get the IGG in next. "Francesca, I AM WORKING ON IT BE PATIENT!" So it is her hopes that these two plus the IGG will get me stable... then once I am there... I will see what she says.... I hope that helps with why I am not doing that protocol... I also asked for a sleep aid and Klimas said WAIT FRANCESCA... give these drugs a chance...

Francesca, the question was aimed at Hip. But have any of Klima's patients actually achieved remission?

 

[lartista]

Francesca, the question was aimed at Hip. But have any of Klima's patients actually achieved remission?

Yes.... I did... What counts as remission? Is cancer in remission cured? Usually not... it is just held down. If you use Dr. Martin Lerners' EIPS "Energy Index Point Scale" and you clock on a report for months where you started and where you can arrive then Yes I know remission is possible for some of us. Not for all of us... Are we cured? NO, NEVER. Are we at risk for relapse through out our life? YES. Do you go to a real ME/CFS specialist? Because if you did, I would guess you knew those answers...

I was a three on the EIPS and I got up to a 7 to 7.5... A three 3 is :
'out of bed sitting, standing, walking 2 - 4 hours a day where as a 7 is: no naps, up 7:00 a.m. to 9:00 p.m. Able to work sedentary job plus light housekeeping. WIll I ever be able to go back to holding done my own company, cleaning my house, running errands, go out to events and be a professional athlete exercising my A_S off... not I do not think that will ever be my reality again...

But after being 100% disabled since 2006 and being sick since 2003... I am totally happy at a 7! I have seen people bed bound... not walking get out of bed without wheelchairs with ME/CFS... So yes there is hope but EVERY case of our is totally different. Klimas had taught me it is trial and error and it takes time... good luck

 

[lartista]

@globalpilot
Isn't Valcyte a totally different type of a/viral to the one/s used in this study though?

yes I did not see Valcyte being used in Pridgen's cocktail.

 

[lartista]

Antivirals could be reducing inflammation by reduce viral load. They should run a study with antivirals on non cfs non viral people to see what happens with inflammation??

When I got into the actual results, Pridgen did test it on ME/CFSers too in this study... Some people got a 100% relief while other got a 60 to 80 % relief... His study though it target FIBRO as the winner with best results, ME/CFSer got relief too but it will be 3 to 5 years before his private label drug is made... In the mean while, shall we all rot? I think not... I just wanted people to know I had gotten huige results with VALTREX - Valacyclovir.... so my guess is if you can talk your doctor into 2 grams a day of that, it is one option...

 

[Jon_Tradicionali]

When I got into the actual results, Pridgen did test it on ME/CFSers too in this study... Some people got a 100% relief while other got a 60 to 80 % relief... His study though it target FIBRO as the winner with best results, ME/CFSer got relief too but it will be 3 to 5 years before his private label drug is made... In the mean while, shall we all rot? I think not... I just wanted people to know I had gotten huige results with VALTREX - Valacyclovir.... so my guess is if you can talk your doctor into 2 grams a day of that, it is one option...

What's the real difference between FM and CFS?

FM patients have more pain.

That's it.

If a drug works for one, it will work for the other.

Where did you get those stats Francesca?

 

[Iquitos]

No, they are not the same. Read the CCC or the New ICC for a definition of ME. And FM patients don't necessarily have more pain than those with ME. Suicide due to unrelieved pain is the third leading cause of death in ME. I haven't heard of any suicides due to FM.

I've used acyclovir and diclofenac for several years and it is certainly not a cure -- not even close. It has helped a lot with neurological issues but very little for pain.

 

[Jon_Tradicionali]

No, they are not the same. Read the CCC or the New ICC for a definition of ME. And FM patients don't necessarily have more pain than those with ME. Suicide due to unrelieved pain is the third leading cause of death in ME. I haven't heard of any suicides due to FM.

I've used acyclovir and diclofenac for several years and it is certainly not a cure -- not even close. It has helped a lot with neurological issues but very little for pain.

I have got every symptom listed on the criteria for CFS and that for FM.

Suicide is another issue altogether...

 

[Iquitos]

You could have a basket of fruit that includes an apple; and you could have an apple separately. That would not make the apple the same as the basket of fruit.

I have some of the painful points required for a FM diagnosis but not all. And I have a great deal of other types of pain that are not FM.

 

[Jon_Tradicionali]

You could have a basket of fruit that includes an apple; and you could have an apple separately. That would not make the apple the same as the basket of fruit.

I have some of the painful points required for a FM diagnosis but not all. And I have a great deal of other types of pain that are not FM.

Unsure where you're going with the comparison of FM to apples and that you don't have FM.

I said ,I, tick every box for criteria of FM as well as CFS. I've never said they are the same, but are very often regarded as in the same class and my belief that it is the same pathogen wuss exhibiting itself in slightly different ways.

Pridgen himself believes a handful of syndromes are caused by HSV. Two of these syndromes are FM and CFS.

 

[lartista]

What's the real difference between FM and CFS?

FM patients have more pain.

That's it.

If a drug works for one, it will work for the other.

Where did you get those stats Francesca?

http://www.faqs.org/patents/imgfull/20130203783_19

Table A
If I read it correctly there were 25 patients for clinically treated responses. Column F was for FIBRO and column J was for CHRONIC FATIGUE. There was a placebo group too... In my opinion there was a group with successful FIBRO scores with PAIN IMPROVEMENT of 50% or more: 100, 80, 80, 76.5, 71.4, 50 and a less successful group with an improvement of 42.9, 37.5, 30, 30, 27.3, 12.5. There is no way to no more than that but PRIDGEN stated there was success with FIBRO...

The ME/CFS groups was as follows: 4 with ME/CFS. Their grades were for improvement in pain: 100%, 62.5, 55.6, and 12.5. There were two with diagnosed with "chronic pain" and they got 75, 70.6 and 25%. In my opinion based on the facts that 1) Pridgen bragged that he found something that workd for FIBRO and sometimes for ME/CFS for parital relief 2) He ran out and patented everything 3) found a drug company to raise money to formulate this drug combination 4) asked my friend to keep it HUSHED and not report on it 5) had a placebo group 6) has successful cases with extreme relief... not a cure... not a fix all but significant relief.... this is what I have concluded....

"If a drug works for one, it will work for the other." I assume you know about these illness and you already know the answer to your own question....

I hope that helps... read the links and invest in researching... I gave you guys the links... Francesca