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http://www.nyas.org/Events/Detail.aspx?cid=0918b8d8-9a46-4334-
b194-23ade9c2a7aa
b194-23ade9c2a7aa
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I wonder why they have not determined yet wheter those are reservoirs or not. Is that so difficult and time consuming to do? Or maybe they don't want to share this information yet?http://www.nyas.org/Events/Detail.aspx?cid=0918b8d8-9a46-4334-b194-23ade9c2a7aa
Disease Associations of XMRV and MLV-Related Viruses
Judy A. Mikovits, PhD, Whittemore Peterson Institute for Neuro-Immune Disease
[...]
Since viral load in peripheral blood is low, these data suggest that B cells in tissues such as spleen and lymph nodes could be an in vivo reservoir for XMRV.
[...]
I wonder why they have not determined yet wheter those are reservoirs or not. Is that so difficult and time consuming to do? Or maybe they don't want to share this information yet?
... and 9/9 positive for clonalTCR gamma rearrangements. Spontaneous development of four immortalized B cells lines occurred during culture of cells from CFS patients.
Can anyone explain this bit in lay language? It would be much appreciated.
TCR = T-Cell receptor. Clonal selection is an active immunological selection proces and is explained here: http://en.wikipedia.org/wiki/Clonal_selection
But this process can go wrong, resulting in a lymphoma or T-Cell leukemia.
http://en.wikipedia.org/wiki/Lymphoma
http://en.wikipedia.org/wiki/Lymphoid_leukemia
The Gamma region is discussed here: http://en.wikipedia.org/wiki/TRG@
The immortalised cell lines are what is used in Cell culture. http://en.wikipedia.org/wiki/Cell_culture
If you take a series of human cells, place them in a test tube and give them essential nutrients, they will merely die. Cancer cells are unique because they will keep replicating, but that is not sufficient for survival as a cell line in a test tube. As far as I know, most immortal cell lines have evidence of viral involvement, often retroviral involvement.