Ive decided to stop the benadryl today, i just couldnt hack this overall feeling that i was doing myself more harm than good, my baseline of cognitive function has been dropping by the day, and depression / toxic feeling was rising, interesting little self experiment non the less that may have given more insight into this whole messy picture, ah well, on to the rifaximin!
Hey
@trickthefox, hope you are doing ok!
Just found this interesting interview with Dr Driscoll, talking about here experience with these issues and her latest research,
http://thelowhistaminechef.com/dr-diana-driscoll-interview-vagus-nerve-and-potsmast-cell-activation/
I found this really interesting: "I remembered from optometry school, like a gazillion years ago, about our lecture on autonomic nerves, that the vagus nerve has 2 components: the preganglionic portion of the nerve that goes from the brain down the neck to the organ be it the heart and lungs, GI tract, or whatever, and then there’s a little gap, what we call a synapse, then there’s the postganglionic portion of the nerve, which is very, very tiny. It’s almost a part of the organ itself. I wondered if my preganglionic nerve was defunct for any reason. I was considering compression at the time. Could I possibly stimulate the postganglionic portion of that nerve and have a bowel movement? As far as I knew, my postganglionic nerve should be okay. I’ve never had surgery on that area. It should be okay. The preganglionic vagus nerve stimulates the postganglionic portion by sending a neurotransmitter, acetylcholine, across that little gap which then stimulates the organ to respond. We can’t use acetylcholine as a drug inside the body because the body immediately breaks it down. Instead, we have to use an imitator, what we call an agonist.
The vagus nerve is also special. It is a nicotinic acetylcholine nerve and a good agonist for this nerve is nicotine. I called my husband and asked him to bring home a nicotine patch. I placed the patch on the lower right hand area of my abdomen, near the ileocecal valve just kind of hoping, and about an hour later things started moving, the ileocecal valve opened and amazingly I had a normal bowel movement. Shocking, right? I couldn’t continue using a nicotine patch because nicotine activates histamine producing cells. I was on fire. It looked and felt like I was being attacked by a swarm of fire ants inside my body. It was horrible, but my response taught me two things and they’re important. First, my receptors were working fine. I did not have some rare autoimmune problem causing my gastroparesis. I did not have a receptor problem. I had a neurotransmitter problem or a problem with the preganglionic portion to my vagus nerve."