• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To become a member, simply click the Register button at the top right.

DOMS (Delayed Onset Muscle Soreness) is Neural Microdamage Rather Than Muscle Damage

Learner1

Senior Member
Messages
6,305
Location
Pacific Northwest
You might try these.
 

Attachments

  • Mitochondrial_Correction Dagostino Seyfried Riordan Nicolson.pdf
    421.7 KB · Views: 33
  • Pall ONOO cure.pdf
    114.5 KB · Views: 29
  • oxidative nitrosative stress in cfs (1).pdf
    320.9 KB · Views: 26

Pyrrhus

Senior Member
Messages
4,172
Location
U.S., Earth
And here's some information from Wikipedia about Delayed-Onset Muscle Soreness (DOMS):

Wikipedia said:
Delayed onset muscle soreness (DOMS) is the pain and stiffness felt in muscles several hours to days after unaccustomed or strenuous exercise.

The soreness is felt most strongly 24 to 72 hours after the exercise.[1][2]: 63  It is thought to be caused by eccentric (lengthening) exercise, which causes small-scale damage (microtrauma) to the muscle fibers. After such exercise, the muscle adapts rapidly to prevent muscle damage, and thereby soreness, if the exercise is repeated.[1][2]: 76

Delayed onset muscle soreness is one symptom of exercise-induced muscle damage. The other is acute muscle soreness, which appears during and immediately after exercise.
Source: https://en.wikipedia.org/wiki/Delayed_onset_muscle_soreness

Note that Delayed-Onset Muscle Soreness (DOMS) is different from Acute Muscle Soreness (AMS)!
 

Pyrrhus

Senior Member
Messages
4,172
Location
U.S., Earth
And here's the abstract:

Have We Looked in the Wrong Direction for More Than 100 Years? Delayed Onset Muscle Soreness Is, in Fact, Neural Microdamage Rather Than Muscle Damage (Sonkodi et al., 2020)
Sonkodi et al. 2020 said:
According to our hypothesis, delayed onset muscle soreness (DOMS) is an acute compression axonopathy of the nerve endings in the muscle spindle. It is caused by the superposition of compression when repetitive eccentric contractions are executed under cognitive demand. The acute compression axonopathy could coincide with microinjury of the surrounding tissues and is enhanced by immune-mediated inflammation.

DOMS is masked by sympathetic nervous system activity at initiation, but once it subsides, a safety mode comes into play to prevent further injury. DOMS becomes manifest when the microinjured non-nociceptive sensory fibers of the muscle spindle stop inhibiting the effects of the microinjured, hyperexcited nociceptive sensory fibers, therefore providing the ‘open gate’ in the dorsal horn to hyperalgesia. Reactive oxygen species and nitric oxide play a cross-talking role in the parallel, interlinked degeneration–regeneration mechanisms of these injured tissues.

We propose that the mitochondrial electron transport chain generated free radical involvement in the acute compression axonopathy. ‘Closed gate exercises’ could be of nonpharmacological therapeutic importance, because they reduce neuropathic pain in addition to having an anti-inflammatory effect. Finally, DOMS could have an important ontogenetical role by not just enhancing ability to escape danger to survive in the wild, but also triggering muscle growth.
 

bread.

Senior Member
Messages
499
And here's the abstract:

Have We Looked in the Wrong Direction for More Than 100 Years? Delayed Onset Muscle Soreness Is, in Fact, Neural Microdamage Rather Than Muscle Damage (Sonkodi et al., 2020)


= likely a mechanism at play or disarray in me/cfs it seems to me
 
Back