Hi jesse, I had a pulse regimen of Azithromycin (3-4 days a week) + Doxycycline every days for 4 months from february to may 2017
yes I know, it's a bit strange, but azithromycin seems to be very quickly absorbed (the peak in the blood is known to be at 2-3 hours after intake), so it is possible that azithromycin put a pressure on mitochondrias as soon as it arrives in the blood, and then the blood lactate control system happens to start out and to regulate the lactate peak.
I have done 167 blood lactate controls on me since I started the monitoring two months ago (just after my 4 months antibiotics regimen), so I'm still under investigations and hypothesis are not closed, you can add yours!
The first curve I made was my post acetyl Salicylic acid lactate curve, a known mitochondria toxic drug that is partly absorbed by the stomach. I took One Alkaseltzer (324 mgr acetyl salicylate) . At this dose, we shouldn't see any toxicity, but the test clearly showed that my blood lactates regulation systems were not very good:
18.05.17 fasting Blood Lactates at 6h30 = 1,7 mmol/l ...intake 1 alkaseltzer (no food)
7h30 BL = 2,9 (alka+1h)
8h30 BL= 3,1 ( alka+2h00 )
9h30 BL = 3,3 (alka+3h00 )
10h30 BL = 2,2 (alka+4h00 )
12h00 BL = 1,8 (alka+4h30 )
The few tests I've done with azithro (without any food intake) said that my lactates has a peak at 1 hour, and then goes low at 1h30
16.07.17
18h10 BL= 2,7 zithromax 250 mg + glass of water then laying
19h14 BL=3,2
19h44 BL=1,9
17.07.17
14h00 BL= 2,7 azythro 250 mg +glass of water
15h00 BL = 3,6
20h15 BL = 2,4 azythro 250 mg + glass of water
22h12 BL = 2,1
18.07.17
13h30 BL = 1,9 azythro + water
14h40 BL = 2,7
19h00 BL = 3 azythro + water
20h00 BL = 3,3
21h00 BL = 2,3
Very interesting. The lactate peak you have observed with Azithro does not fit the absorption peak you mentioned though. So unless you are absorbing Azithromycin faster than normal, then I think it is probably some effect that Azithromycin in having on your gut itself.
Have you ever measured your day-to-day lactate on and off Azithro? I would love to see a study done on that, or on Rapamycin.