Does Low Dose Naltrexone (LDN) reduce inflammation?

[ebethc]

Hi - does anyone know if LDN reduces inflammation? It does a good job on pain, not sure beyond that, though.

thanks

 

[Sushi]

@ebethc
Many report that it does, but I don't have documentation handy.

Sushi

 

[ahmo]

* Summary of Stanford Study on Low Dose Naltrexone (LDN) ***

Last updated September 7, 2014 Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962576/

Conclusions

The totality of the basic and clinical research to date suggests that LDN is a promising treatment approach for chronic pain conditions thought to involve inflammatory processes. The clinical data supporting its use are very preliminary, and more research is needed before the treatment approach can be widely recommended. Critical parameters such as dosing still need to be refined. LDN may emerge as the first of many glial cell modulators that could be used to treat chronic conditions, with more specifically targeted medications developed in the future. As conventional anti-inflammatories have poor blood brain-barrier permeability, we expect centrally active immune modulators to be an area of interest in the future.

You can check these sites, there might be further info:
http://www.lowdosenaltrexone.org/index.htm

https://sites.google.com/site/dudleyslowdosenaltrexonesites/

 

[Hip]

LDN may reduce microglial activation, which is a central part of brain inflammation.†

 

[ebethc]

@Sushi @ahmo @Hip

I took TONS of vegetarian DHA yesterday and it made a dramatic (positive) effect on inflammation! Sinuses, throat, lungs all feel so much better, plus aches & pains. For some reason, the vegetarian (algae-sourced) DHA is much better for me than the fish-sourced DHA... I've been really sick all month after going on a gene protocol that included Arginine in early september... the arginine made my EBV flair..

I took some leftover LDN 2 days ago and it really made my symptoms flare... It worked okay for me in the past, and I thought I'd try it again now that I've given up dairy & gluten. My body really didn't go for it this time around...

 

[fibrodude84]

LDN has shown in small trials to potentially reduce inflammation in inflammatory bowel disease (crohns and colitis)

 

[nomad]

I would be very keen to try this if its possible to get a private prescription for it. Anyone ?

I have CFS, along with painful cramped muscles, and severe anxiety which leads me to suspect inflammation, particularly brain inflammation.

 

[CantThink]

I took some leftover LDN 2 days ago and it really made my symptoms flare... It worked okay for me in the past, and I thought I'd try it again now that I've given up dairy & gluten. My body really didn't go for it this time around...

Could it have been a herxheimer reaction? Every time I increased (or initially took) LDN I'd get a 5-7 day herxheimer before I saw improvement. It was quite scary the first time. I got used to it and although I found it unpleasant, I found it okay to deal with if I knew I'd see improvement afterwards.

 

[CantThink]

I would be very keen to try this if its possible to get a private prescription for it. Anyone ?

I have CFS, along with painful cramped muscles, and severe anxiety which leads me to suspect inflammation, particularly brain inflammation.

If you are in the UK

http://www.ldnresearchtrust.org/LDN_Prescribing_Doctors

http://www.dicksonchemist.co.uk/LowDoseNaltrexone/Default.aspx

http://www.prescribe4me.co.uk/LowDoseNaltrexone/Default.aspx

 

[nomad]

Thanks @CantThink I hope they can prescribe without me still not having a definete diagnosis

 

[CantThink]

Thanks @CantThink I hope they can prescribe without me still not having a definete diagnosis

If they don't, you can get it from abroad with no prescription. You can buy the 50mg tablets - look up 'Preparing LDN at home' on Google.

 

[Ema]

You can even get it now from IAS in 4.5 mg strength if you don't want to mess with dilution.

 

[Sushi]

I now get the 50 mg generic tablets from my local pharmacy (prescription required). It is very cheap and very easy to dilute--50 mgs in 50 mls: 1 ml = mg.

Sushi

 

[ebethc]

You can even get it now from IAS in 4.5 mg strength if you don't want to mess with dilution.

What is IAS?

thanks

 

[heapsreal]

https://www.buyldn.com/ldn-4-5.html

 

[Ema]

What is IAS?

thanks

http://www.antiaging-systems.com/113-naltrexone

 

[Sushi]

It is really expensive at those 2 sources --I guess it is the trade-off for not requiring a script.

 

[Dufresne]

Does anyone know where I can buy brandname Revia without a prescription at an affordable price?

 

[knackers323]

Does LDN tend to improve fatigue levels?

 

[Ema]

I guess I need to shop around...both of those sources are cheaper than my local compounding pharmacy with a script.

Where do you get yours, @Sushi?

ETA: Sorry, Sushi, missed your post above.