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Does anyone else have low ferritin and normal red blood cells?


Senior Member
small town midwest
Seems like there might be a connection between low iron and mast cell problems.


Linking iron-deficiency with allergy: role of molecular allergens and the microbiome​


Atopic individuals tend to develop a Th2 dominant immune response, resulting in hyperresponsiveness to harmless antigens, termed allergens. In the last decade, epidemiological studies have emerged that connected allergy with a deficient iron-status. Immune activation under iron-deficient conditions results in the expansion of Th2-, but not Th1 cells, can induce class-switching in B-cells and hampers the proper activation of M2, but not M1 macrophages. Moreover, many allergens, in particular with the lipocalin and lipocalin-like folds, seem to be capable of binding iron indirectly via siderophores harboring catechol moieties. The resulting locally restricted iron-deficiency may then lead during immune activation to the generation of Th2-cells and thus prepare for allergic sensitization. Moreover, iron-chelators seem to also influence clinical reactivity: mast cells accumulate iron before degranulation and seem to respond differently depending on the type of the encountered siderophore. Whereas deferoxamine triggers degranulation of connective tissue-type mast cells, catechol-based siderophores reduce activation and degranulation and improve clinical symptoms. Considering the complex interplay of iron, siderophores and immune molecules, it remains to be determined whether iron-deficiencies are the cause or the result of allergy.
I do. My hemoglobin and erythrocytes are normal but ferritin is low. I don’t think i have MCAS but i do have HI. It’s very well managed with diet and quercetin though.


Senior Member
I was just wondering...

Is this something that goes with ME/CFS generally or is it my period? Did anyone with low iron take supplements and feel better?
I had low ferritin all my life but usually normal red blood cells (anemia only on one occasion when my ferritin was at it's worst).

Low ferritin is a risk factor for ADHD and restless legs.
Low ferritin produces low dopamine in the brain, and low dopamine can drive pain and sleepiness.

I found that iron supplementation helps me a bit with both pain and sleepiness.

Keep in mind that low ferritin can be a sign of poor iron intestinal absorption and also that some gastric diseases can cause low ferritin.