Countrygirl, your reference to Leicester and isolation was slightly misleading (possibly not intentionally):
'The global eradication effort, led by D.A. Henderson, originally used a strategy of mass vaccination campaigns to achieve 80% vaccine coverage in each country. This goal proved difficult to attain in many underdeveloped countries, but a serendipitous discovery led to a more effective strategy. Insufficient vaccine supplies in Nigeria led Dr. William Foege to try a strategy of aggressive case-finding, followed by vaccination of all known and possible contacts to seal off the outbreak from the rest of the population.
5 This was the first time such a strategy was employed during the global smallpox eradication campaign, although it was also used in Leicester, England in the late 19th century.
9 This strategy, known as surveillance-containment or ring vaccination, led to the disappearance of smallpox in eastern Nigeria even though the population coverage was less than 50%. The relative benefits of ring vaccination versus mass vaccination have been debated, but epidemiological evidence from Africa and Asia suggests that both lower population density and higher population vaccine coverage contributed to the elimination of transmission in many regions.'
10
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1069029/
This account of the Leicester Method states that vaccination and isolation were used concurrently.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1082657/