If you look at the list of
PEM Buster supplements that various members of this forum have identified, high dose Q10 in the range of 800 mg to 2,000 mg daily seems to have potent anti-PEM effects for some ME/CFS patients. The mechanism of action may in part be Q10's ability to reduce lactate levels produced by exercise (a
study found Q10 reduces lactate in myotonic dystrophy), and possibly may also relate to Q10's important role in mitochondrial oxidative phosphorylation.
I am not sure how many other members of this forum have tried to replicate these Q10 anti-PEM effects, to see if it can instantly curtail their own PEM with these high doses. I can't really test this much on myself, because don't get much PEM from physical exercise, mainly just PEM from mental exertion.
There have been two studies on the benefits of Q10 for ME/CFS: one study found Q10 may increase
energy in ME/CFS (ref:
1), and another found 150 mg of Q10 daily improves
cognitive function and
autonomic dysfunction in ME/CFS (ref:
1).
Taking doses at those levels would be ridiculously expensive. I'm paying about £30 per month to take 200mg daily.
You can get some amazingly good prices for Q10 powder on
AliExpress.com, typically around $200 for 500 grams of Q10 98% powder. This is where I buy my Q10. This Chinese Q10 powder has this nicest, cleanest taste of any Q10 powder I have tried.
So
@Jan, for your jar of 30 x 200 mg Q10 capsules, you are paying £30 for what amounts to a total of 6 grams of Q10.