No I'm not aware of a golden bullet but some Flavonoids can lower cytokines, maybe you can find something in here: MCAD treatmentDo you have suggetsions on how to lower these markers?
Unfortunately my physicians haven't taken any interest in these results, since they aren't directly diagnostic of anything (no surprise) nor point to any intervention.Have you found what's driving them? It might lead to something treatable.
IL-4 is related to allergy, mast cell, and autoummunr diseases, as well as neurological diseases like Alzheimer’s MS, and glioblastoma multiforme.
According to Self Decode, TGF-beta plays an important role in autoimmune diseases, food intolerances, cancer, cognitive function, wound healing and other diseases. It has pro- and anti-inflammatory effects, and:
- Causes collateral damage in infections
- Causes the growth/changes in tissue
- Decreased acetylcholine
- Decreased slow wave or deep sleep
- Decreases muscle regeneration
- Decreases the action of the vitamin D receptor
- Increases free radicals
- Can decrease bone density
- It inhibits proliferation of most other cell types
- Suppresses red blood cell formation and lymphocytes (T and B cells)
- Suppresses antibody production
- Suppresses Cytotoxic T Cell (CD8) and Natural Killer cell activity...this can cause viral infections to get out of control.
- Deactivates macrophages
- Promotes oral tolerance
- Suppresses inflammation
- Promotes wound healing and new blood vessel formation (angiogenesis)
- Induces local inflammation and fibrosis
- Stimulates extracellular matrix deposition
- Promotes switch to IgA
- Can increase cancer growth
- Cause negative changes in the airways
- Can benefit cognitive function (when very mildly elevated)
Yes my ECP is also elevated above maximum but not as severely as VEGF for example.@mitoMAN If mast cells are firing then eosinophils are probably activated as well. You could check for eosinophil cationic protein (ECP) at IMD, it's a unique molecule for eosinophils.
Can ECP be taken as an additive MCAS marker? Never saw it listed together.@mitoMAN If mast cells are firing then eosinophils are probably activated as well. You could check for eosinophil cationic protein (ECP) at IMD, it's a unique molecule for eosinophils.
NoCan ECP be taken as an additive MCAS marker?
Cytokines are just effects following tissue damage not causes so this won't cure ME.
Has no one bothered to try injecting (or pills if possible) the various cytokines into PWME to see whether a specific one is responsible for triggering symptoms? It seems like a reasonable approach to me. It wouldn't require mega-doses, just the level normally created by infections, red meat, etc. I'm sure there's be volunteers for something that might help in understanding ME.
Or you can just change your diet.
Has no one bothered to try injecting (or pills if possible) the various cytokines into PWME to see whether a specific one is responsible for triggering symptoms?
That wouldn't determine if a specific cytokine was involved with ME symptoms. Raising them individually (or in sets) would show whether that's part of the mechanism of ME. Dietary change might make a person feel a bit better, but it wouldn't increase understanding of what causes ME symptoms.
Neither will measuring cytokines in blood since they are nonspecific.