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What’s the difference between the nanoneedle and off-the-shelf impedance analyzers? Can off-the-shelf counterparts separate ME/CFS PBMCs with ME/CFS plasma from those with healthy plasma? And while utilizing the salt-stress test?
Here’s a summary of how 2 impedance analyzers work:
It’s of interest that the xCELLigence system can measure changes in morphology. Maybe this could be used to replicate Prusty’s findings [4] about changes in mitochondrial morphology.
So, could this be a viable avenue of searching for the “something in the blood?”
Here’s a summary of how 2 impedance analyzers work:
- Nanoneedle: “The assay detects any impedance modulation due to the presence and/or interactions of biomolecules of interest at the active sensing region of the sensors [1].”
- xCELLigence RTCA: “Changes in morphology, adherence and cell numbers lead to impedance shifts reflected as cell index (CI) alterations which are dynamically recorded using the instrument [2][3].”
It’s of interest that the xCELLigence system can measure changes in morphology. Maybe this could be used to replicate Prusty’s findings [4] about changes in mitochondrial morphology.
So, could this be a viable avenue of searching for the “something in the blood?”