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This thread is related to the article I uploaded to the forum. I would like to know whether a number of markers that I propose at the end of the article are met.
It is aimed at people who have had CFS post-Epstein Barr virus infection.
I therefore propose that we pool these markers in order to be able to classify this sub-group of CFS. I would like each person to put the following:
- Pathogen causing your CFS: EBV
- Number of antibodies against EBNA IgG. These antibodies to this latent protein should be elevated due to chronic latent infection, as in multiple sclerosis.
- Number of activated T-lymphocytes CD3 + HLA-DR +. They should be decreased by the expression deficit of MHC class II molecules.
- Molecular typing of the HLA system. For example: HLA-DR15 and HLA-DQ6 predispose to developing multiple sclerosis but together with more factors. Depending on the type of HLA it will indicate a greater or lesser genetic susceptibility to have difficulties in controlling this infection. HLA-DR would be the most interesting type of HLA in this case, because DR is a class II MHC molecular type.
If you have any questions or doubts, ask me by this thread.
Greetings and thank you very much for your cooperation.
It is aimed at people who have had CFS post-Epstein Barr virus infection.
I therefore propose that we pool these markers in order to be able to classify this sub-group of CFS. I would like each person to put the following:
- Pathogen causing your CFS: EBV
- Number of antibodies against EBNA IgG. These antibodies to this latent protein should be elevated due to chronic latent infection, as in multiple sclerosis.
- Number of activated T-lymphocytes CD3 + HLA-DR +. They should be decreased by the expression deficit of MHC class II molecules.
- Molecular typing of the HLA system. For example: HLA-DR15 and HLA-DQ6 predispose to developing multiple sclerosis but together with more factors. Depending on the type of HLA it will indicate a greater or lesser genetic susceptibility to have difficulties in controlling this infection. HLA-DR would be the most interesting type of HLA in this case, because DR is a class II MHC molecular type.
If you have any questions or doubts, ask me by this thread.
Greetings and thank you very much for your cooperation.
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