Diagnosing Hypoxemia - Any doctors actually think about a problem - first principles?

[Violeta]

Is the problem that the adenosine builds up because it isn't being metabolized. Is the problem a lack of adenosine deaminase activity?

A lack of adenosine deaminase activity might also be the cause of caffeine sensitivity?

Adenosine deaminase stability is affected by zinc.
" Real-time 19F-NMR spectroscopy measuring the loss of Zn2+ showed that structural changes correlated with the loss of enzymatic activity."

The Role of Zn2+ on the Structure and Stability of Murine Adenosine Deaminase
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3005954/


Evidence of functional zinc deficiency in Parkinson's disease
https://pubmed.ncbi.nlm.nih.gov/10100031/#:~:text=Patients with PD showed a,loss (p < 0.05).

The single most consistent finding and the strongest environmental risk factor associated with RLS is iron insufficiency. Professor Nordlander first recognized the association between iron deficiency and RLS, and reported that treatment of the iron deficiency markedly improved, if not eliminated, the RLS symptoms.

I suggest that zinc deficiency is related to the iron insufficiency of RLS.

"We have demonstrated that zinc induces iron uptake and transcellular transport in intestinal cells via induction of DMT1 and FPN1 expression [16,17,19,20]. Therefore, zinc appears to be a key modulator of intestinal iron absorption and tissue iron distribution possibly mediated via regulating the DMT1 and FPN1 levels."

 

[Violeta]

Adenosine: Risks and 4+ ways to lower it.

"Zinc is the most important natural substance that increases the activity of ADA, the main enzyme that breaks down adenosine and reduces its levels. Zinc acts as a cofactor that this enzyme needs in sufficient levels to work well [88]."

Note: Caffeine is not advised.

https://selfhacked.com/blog/adenosine-risks/

 

[pgrovetom]

Adenosine deaminase stability is affected by zinc.
" Real-time 19F-NMR spectroscopy measuring the loss of Zn2+ showed that structural changes correlated with the loss of enzymatic activity."

The Role of Zn2+ on the Structure and Stability of Murine Adenosine Deaminase
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3005954/


Evidence of functional zinc deficiency in Parkinson's disease
https://pubmed.ncbi.nlm.nih.gov/10100031/#:~:text=Patients with PD showed a,loss (p < 0.05).

The single most consistent finding and the strongest environmental risk factor associated with RLS is iron insufficiency. Professor Nordlander first recognized the association between iron deficiency and RLS, and reported that treatment of the iron deficiency markedly improved, if not eliminated, the RLS symptoms.

I suggest that zinc deficiency is related to the iron insufficiency of RLS.

"We have demonstrated that zinc induces iron uptake and transcellular transport in intestinal cells via induction of DMT1 and FPN1 expression [16,17,19,20]. Therefore, zinc appears to be a key modulator of intestinal iron absorption and tissue iron distribution possibly mediated via regulating the DMT1 and FPN1 levels."

Please review some key recent research:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766678/
https://pubmed.ncbi.nlm.nih.gov/29358902/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444903/

I'm being a bit glib saying adenosine causes RLS but recent research shows adenosine and its cycles daily are deeply involved in RLS and iron deficiency is a common trigger and dopamine agonists interfere with the adenosine pathway in such a way to ease the symptoms.

 

[pgrovetom]

Adenosine deaminase stability is affected by zinc.
" Real-time 19F-NMR spectroscopy measuring the loss of Zn2+ showed that structural changes correlated with the loss of enzymatic activity."

The Role of Zn2+ on the Structure and Stability of Murine Adenosine Deaminase
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3005954/


Evidence of functional zinc deficiency in Parkinson's disease
https://pubmed.ncbi.nlm.nih.gov/10100031/#:~:text=Patients with PD showed a,loss (p < 0.05).

The single most consistent finding and the strongest environmental risk factor associated with RLS is iron insufficiency. Professor Nordlander first recognized the association between iron deficiency and RLS, and reported that treatment of the iron deficiency markedly improved, if not eliminated, the RLS symptoms.

I suggest that zinc deficiency is related to the iron insufficiency of RLS.

"We have demonstrated that zinc induces iron uptake and transcellular transport in intestinal cells via induction of DMT1 and FPN1 expression [16,17,19,20]. Therefore, zinc appears to be a key modulator of intestinal iron absorption and tissue iron distribution possibly mediated via regulating the DMT1 and FPN1 levels."

I do not believe there is a "pat" answer but adenosine metabolism and the pathways play key roles in many conditions including cancer, cardiac function, stomach acidity, RLS etc.... Its very complicated but using caffeine is just asking for trouble.

 

[Violeta]

--- I've taken iron supplements to see if I can increase red blood cell count or hemoglobin O2 carrying capacity with no real effect. My CBCs show normal hemoglobin and red blood cells

Do you know why iron supplementation didn't help you?

Did you try any dopamine agonists?

Other ways of dealing with adenosine are being investigated because they know that:
At the same time, dopamine agonists have risks and side effects associated with prolonged use or high doses. Dopamine agonists can be a useful treatment that enhances the quality of life, but they require careful administration and monitoring of symptoms to ensure safe use.

I am just wondering why some people have such problems with adenosine. There must be some root cause.

 

[pgrovetom]

No, I tried a variety of carefully chosen iron supplements with no change. I have used the dopamine agonist with success. It has only minor effects when the RLS begins to move up my body. In retrospect I may have taken 200 MG caffeine pills on the days of bodywide RLS. For bodywide RLS, just imagine the same building up feeling not just beginning in the feet moving up, imagine the exact feeling in torso and reaching as high as my chest.

I have a 600kb MEDIA (mitochondrial) deletion in my skeletal muscles and it 100% disables the electron transport chain and therefore no ATP can be produced. The main source of ongoing adenosine is the breakdown of ATP, ADP, AMP and CCAMP it is eliminated via enzymatic conversion to inositol. Failure to produce these essential intermitites by broken mitochondria can cause excess and circadian tried innspropriate levels.

Adenosine is in the top 10 metabolites in importance on a circadian basis in the entire body. It's dysregulation on a circadian basis ( levels as the daily cycle proceeds) has been linked to a variety of neurogenerative condtions, cancers, immune problems. Gi issues RLS and more.