DHT - dihydrotestosterone

knackers323

Senior Member
Messages
1,482
Likes
485
I’ve been taking the DHT based steroid proviron and feeling much better.

Regular non DHT steroids have not had the same effect

The benefits are pretty impressive so I’m wondering if it’s just the standard effects from altering hormone levels that is having the impact or it’s some other mechanism

As CFS, and to my knowledge, autoimmune diseases in general effect women more than men, I’m thinking that the male hormone DHT might be having some effect on a possible autoimmune process

Anyone aware of the role of DHT in autoimmune illnesses?

@Hip you aware of anything?

Has anyone else tried proviron or similar?
 

Wishful

Senior Member
Messages
1,232
Likes
1,716
Please let us know if it continues to work after couple of weeks. Some of us have had beneficial responses to prednisone or other steroids, but they stopped working after the first course or two. I had effective remissions the first two courses of prednisone, but I tried it twice after that with no noticeable effect.

Unexpectedly, cumin seed had the same effect as prednisone (after my doctor wouldn't prescribe any more), but that stopped working too after a week or so.
 

heapsreal

iherb 10% discount code OPA989,
Messages
9,081
Likes
8,534
Location
australia (brisbane)
I’ve been taking the DHT based steroid proviron and feeling much better.

Regular non DHT steroids have not had the same effect

The benefits are pretty impressive so I’m wondering if it’s just the standard effects from altering hormone levels that is having the impact or it’s some other mechanism

As CFS, and to my knowledge, autoimmune diseases in general effect women more than men, I’m thinking that the male hormone DHT might be having some effect on a possible autoimmune process

Anyone aware of the role of DHT in autoimmune illnesses?

@Hip you aware of anything?

Has anyone else tried proviron or similar?
What dose of proviron you taking? Its well known for increasing free testosterone levels for guys already on testosterone replacement therapy plus TRT theres always some conversion to dht.

Non dht based steroids for guys i think can maybe help someone with anxiety or they can make others lethargic after 4 to 6 weeks like deca/ nandrolone.

Testosterone itself can be energising through dht but also through dopamine pathways which than effects adrenaline/noradrenaline. Not sure if dht has an effect on dopamine but possible.
 

Hip

Senior Member
Messages
11,779
Likes
20,244
From what I can make out from the Wikipedia article, I don't think mesterolone (Proviron) specifically acts on the dihydrotestosterone (DHT) system. The hormones DHT and testosterone both activate the androgen receptor (AR), which is their biological target, but DHT more potently activates the AR than testosterone.

So mesterolone is just another compound that activates the AR.


Have you tried any other testosterone increasing protocols, such as the herb Tribulus terrestris, which is thought to raise testosterone? Or testosterone replacement therapy? Then you could compare the effects to those of mesterolone.

If your testosterone levels are low, then testosterone replacement (and presumably mesterolone as well), will have a mood-boosting, motivation-boosting and energizing effect. Men in their 40s often find their motivation and mood flagging because of lower testosterone (testosterone levels decline by about 1% to 3% a year after around 40).


Are you noticing any aggression side effects? I find testosterone-boosters like Tribulus terrestris do boost mood, but also have the side effect of making me short-tempered and generally always feeling angry, which is not a nice mental state, so for that reason I rarely use Tribulus terrestris.
 
Last edited:

heapsreal

iherb 10% discount code OPA989,
Messages
9,081
Likes
8,534
Location
australia (brisbane)
@Hip ive never got much out of test boosters. Explanation i saw was that if someone low T increased their T levels by 50%, its not significant to do a great deal eg T level of 250 would go up to 375 so still in the low normal range.

Id say my mood on TRT and having levels in the high range like 900 to 1000 improves mood, no anger if anything you become more assertive, more resistent to stress. A number of guys ive read about say the roid rage thing rarely occurs, its just makes normal dickheads, bigger dickheads lol. Trenbolone is different from what ive read but then again its only been approved for cattle.

Big lesson is to stick with approved steroids for humans and use them in doses used for hormone replacement. It seems many of the TRT clinics in america use testosterone and a few other will add a low dose of deca/nandrolone as it has joint and muscle repairing and pain relieving effects and for cfsers can improve immune function. Total dose of a single drug or combination is usually limited to max of 250mg per week.
 

junkcrap50

Senior Member
Messages
418
Likes
625
I’ve been taking the DHT based steroid proviron and feeling much better.
How do you get the drug Proviron? Are you outside the US? It's illegal in the US.

What dose of proviron you taking? Its well known for increasing free testosterone levels for guys already on testosterone replacement therapy plus TRT theres always some conversion to dht.
It raises free testosterone because it lowers and binds to SHBG (sex hormone binding globulin), which binds to and consumes testosterone, lowering free testosterone levels.
 
Messages
18
Likes
18
I know testosterone suppresses the immune system. And I also know that DHT is like super testosterone (potency estimates range from 3-20 times as strong as regular test, but most bioassays tend to be within the 5-10x range). So knowing this, I’d assume that it would have a greater immunosuppressant effect. The only thing that I’m aware of that it can’t do that testosterone does is, DHT cannot bind to the muscles. It gets broken down by 3alpha-HSD before it can reach the muscle, which is sad because then we’d all be super strong right now haha. A lot of pro bodybuilders take 5alpha-reductase inhibitors to stop the conversion of test to DHT, and some have noticed that while they gain more muscle, they also conversely lose strength. I believe this is because DHT enhances the nerves in the neuromuscular system. These are just anecdotal observations though, they haven’t been studied in a controlled setting (likely due to ethical and monetary reasons lol).
 
How do you get the drug Proviron? Are you outside the US? It's illegal in the US.
Just because it’s illegal here in the States does not mean you can’t get it. Here’s a website that I found after Googling “buy proviron”:
https://www.buyonlineventolin.com/h...-25-mg-20-tablets-ingredient-mesterolone.html
Here’s another one:
https://steroid-pharm.com/proviron.html
And another:
https://valkyrie-online.net/mr-proviron-25
This one looks like it has the best deal though:
https://www.cobraintpharmacy.com/product/proviron-mesterolone-25-mg-x-20-pills-per-package/
These guys talk about other stuff related to it too if you’d like to give it a go:
https://www.isarms.com/forums/source-talk/best-source-proviron-13190.html
 

heapsreal

iherb 10% discount code OPA989,
Messages
9,081
Likes
8,534
Location
australia (brisbane)
know testosterone suppresses the immune system.
Read up about testosterone and nandrolone on hiv patients. You will gind it increases immune function and there is a study somewhere showing ot increasing nk function in hiv patients.

When hormones/steroids are mentioned about being no good for immune system, its generally referring to referring to catabolic steroids like prednisone, so totally different steroids to testosterone or Deca durabolin.

Built to survive, is a book about anabolic steroids on hiv patients isxworth a read.