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Decreased oxygen saturation upon exertion


Senior Member
ME/CFS is estimated to effect 2.5-5% of the population, that's not rare.
This is a blatantly ridiculous estimation of the prevalence of ME. The paper the blog author cites does not list prevalence as a range from 2.5-5% - as far as I can tell, she made those numbers up. And the high end comes from self-report, usually with bad explanation of symptoms, and even the 2% range comes from psychobabblers who have literally redefined ME as mere chronic fatigue.

The author's claim that she is referring to "CFS" rather than "ME" should be enough to show that blog is highly irrelevant to ME/CFS patients. She's looking for a soft target where she feels more comfortable making quack claims.
There are many overlapping symptoms between ME/CFS, CFS, Fibromyalgia, Ehler's Danlos, even Chiari Malformation.
And there are many very distinct symptoms which have resulted in these disorders being separately defined. And many distinct lab results in patients in published studies. I see no support for the claim that they overlap in any meaningful manner - they may have 1 or 2 symptoms in common, but so do thousands of other diseases.
What many of these sufferers have in common is a methylation problem.
Yeah, just like 75% of the rest of humanity, according to the "standards" set by Yasko. The data I have from ME patients with PEM on this forum shows that our rates of methylation SNP variations are pretty much identical to ethnically matched controls.
Your (and her) claims regarding SNPs seems to come from a 2012 unpublished poster presentation at mthfrliving.com/public_files/mthfr_fms_cfs_anderson_study.PDF . Meaning it has not been peer-reviewed or accepted for publication. There also seem to be no controls in the study, with comparisons being made to a rather different (non-local) population ... including Australia.

Patients had "CFS or FM" ... meaning an unknown number of patients didn't have CFS at all, so it would be impossible to guess the relevance. Fortunately the methodology is so poor that we don't have to worry about who the results apply to ... The selection process is not suitably described, so is not clear if the any of 88 "CFS/FMS" patients were found to have MTHFR variants before or after they were included in the study.

The questionnaires used were not good. One was for fibromyalgia, and the other states things in a very dangerous way for ME patients ... listing activities which are "impossible". Few activities are "impossible", they just make us very sick afterward, hence might be especially susceptible to bias. No objective measurements were used.

There is no information given regarding the calculation of statistics. No p-values, no effect sizes. And the one "significant" is used, it's impossible to tell if it's being used in the scientific sense, or as a layman would use it.

All of the patients selected to be treated (selection methodology not listed) had had many IV treatments involving B vitamins and high doses of methylB12 prior to being selected for the study. Thus the "researcher" already knew how they would react to much of the treatment protocol. And there is no indication of when baseline measurements were taken - at the beginning of the study, or at intake into the clinic before receiving infusions and being selected. There was also no control group for the treatments, which is especially relevant when receiving the treatment in a medium which itself can be a treatment, namely IV fluids.

In summary, the study which the blog's claims are based upon is complete junk.

YLime, thanks for that,I didn't know the low blood oxygen thing could come about as a part of having the MTHFR mutation which I do have.
It can't. There is no evidence whatsoever to support such a statement. It's a matter of someone saying "I have symptom X and SNP Y, ergo I believe SNP Y causes X." It's completely absurd.

Little Bluestem

All Good Things Must Come to an End
I was not monitoring my O2 before I started the B2 protocol.

When I ran out of the supplements, my O2 would drop on exertion. When I got started again, my O2 was more stable.