Given that many ME/CFS patients have chronic reactivations of herpes family viruses, might this make them prone to false positive Lyme tests?
In Western Blot some cases of false negative are documented. According to Sam Donta (Boston University) you have a 30% of seronegative Lyme patients, when you deal with chronic infection.
PCR for borrelia is also highly specific, there are no false positive. PCR has a very high specificity and a low sensitivity, expecially in blood; this is due to the fact that borrelia hides in tissues, so you can't find it in the blood stream, but for the first days from the infection.
For LTT I don't know of any proof of cross reactivity, at present. But I guess that this test needs further studies.
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