@FMMM1 @adambeyoncelowe @Gingergrrl
OK so here is my version and hypothesis in a nutshell. The place where all ends meet is the Liver. I have :
-Several Fibroscan tests suggesting LIver Fibrosis
-Several Tests with elevated Total Bile Acids (TBAs) a simple blood test which by the way has not been performed to any ME/CFS patient from anyone (...!)
-Several ME/CFS Patients having removed their Gallbladder, getting Hepatitis at some point, seen white stools (Cholestasis), Having Gallbladder stones, having "Rocky Mountain Fever", Toxic levels of Copper (=Wilson's Disease), Elevated Bilirubin (=Gilbert's Syndrome), EBV, Lyme Disease. What do all of these have in common?
Yes, they all stress the Liver (aka "Liver Stressors")
Complete list here :
https://docs.google.com/spreadsheets/d/1CLtqxW0-L8f25ZXD2H6FFDVbggc73GGC8KtYNkjdUBo/edit?usp=sharing
Now let's move on to the "autoimmune" side. In the 32-page document i sent to many ME/CFS Researchers i explain how the LXR Receptor along with Bile Acid and Phospholipid Dysregulation (Think of Naviaux and Hanson findings here) and Vitamin K Metabolism may set the stage for Inflammation and Autoimmunity. Here is the snapshot (Note that Gas6, ProS, Mer are Vitamin K related):
Also, did you know that we have "Drug Induced" Lupus ? (
https://en.wikipedia.org/wiki/Drug-induced_lupus_erythematosus)
Could this be just another way (drugs may put stress on the Liver) that disrupt these Pathways and result to autoimmune disease?
Can disruption or impaired functioning of these pathways be responsible for all autoimmune disease?
I do apologise for losing my patience.
This hypothesis is quite easy to look at, just ask all ME/CFS Patients for any of these Conditions seen in the Google Sheet plus any medications they took
before ME/CFS.
The reason for not circulating the document is because i do not want people to start experimenting with themselves. I asked from all researchers i contacted to test under medical supervision the usefulness of this Regimen. No reply so far.
And my last question : If an ME/CFS patient has undiagnosed Wilson's Disease will "Metabolic Trap" work? The following dialog just in today :