D-lactic Acidosis: Successful Suppression of D-lactate–Producing Lactobacillus by Probiotics [Aug 2018]

[flipsliptrip]

http://pediatrics.aappublications.org/content/142/3/e20180337

 

[flipsliptrip]

Apologies, I accidentally submitted the post before finishing it. All credit goes to a Reddit thread I found, which I hope others here may find helpful

https://www.reddit.com/r/HumanMicrobiome/comments/9c34us

TL;DR: Some probiotics can cause D-Lactic acidosis and others can cure/prevent it.

Full: https://sci-hub.tw/https://doi.org/10.1542/peds.2018-0337

The strains used were L. GG, B. Lactis BS01, B. Breve BR03, B. Longum BL03.

 

[flipsliptrip]

I believe I caused problems for myself by regularly taking a probiotic which contains D-Lactate producing bacteria while also undergoing immunosuppressive treatment (very silly in hindsight, I just understood it was a general "helps digestion" supplement).

I'm taking a probiotic with a series of the Bifidus species mentioned above (although not the exact same strains, which are more pricey) as well as a no-carb diet to see if things improve.

 

[Judee]

I'm taking a probiotic with a series of the Bifidus species mentioned above

Ken Lassessen talks about Emmental Cheese and the bacteria it contains (Propionibacterium freudenreichii) being food for bifidophilus: https://cfsremission.com/2014/01/27/propionibacterium-freudenreichii-another-probiotic-of-interest/

He also mentions apples and I believe sesame possibly as increasing bifidophilus though I can't find those pages on his site as easily.

 

[JES]

Interesting, but the treatment is nothing novel. The probiotic cocktail they mention was:

Therefore, a probiotic cocktail with non-D-lactate–producing bacteria (Pro4-50 D-Lactate Free Multistrain Probiotic capsules [Spectrumceuticals, Sydney, Australia] containing 25 billion colony-forming units [CFUs] of L rhamnosus GG, 15 billion CFUs of Bifidobacterium (B) lactis BS01, 5 billion CFUs of B breve BR03, and 5 billion CFUs of B longum BL03) was introduced into his daily treatment.

These are among the most common probiotic strains you can find on the market. L. rhamnosus GG can be found everywhere in my country even as a stand-alone probiotic.

So as long as the probiotic mixture does not contain D-lactate producing strains, it should be very easy to trial this and people with ME/CFS have already tried these common strains at least.

 

[datadragon]

Anaerostipes caccae and the two Anaerobutyricum species, A. soehngenii and A. hallii were described to be capable of converting d‐ and l‐lactate plus acetate to butyrate via the acetyl CoA pathway https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7702098/ As there is low acetyl CoA from low butyrate, looks like you need sodium butyrate to restart that process. No more itaconate shunt.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333934/

A reminder that in the fecal metabolome, the % butyrate was increased in the NoPEM group compared with both the PEM and control groups...

 

[flipsliptrip]

Interesting, but the treatment is nothing novel. The probiotic cocktail they mention was:



These are among the most common probiotic strains you can find on the market. L. rhamnosus GG can be found everywhere in my country even as a stand-alone probiotic.

So as long as the probiotic mixture does not contain D-lactate producing strains, it should be very easy to trial this and people with ME/CFS have already tried these common strains at least.

L. rhamnosusus GG is definitely very common (Culturelle), but the other strains are not common at all. Even most probiotics advertising Bifidobacterium species (B. Lactis, B. Breve, B. Longum) will not contain these specific strains (B. Lactis BS01, B. Breve BR03, B. Longum BL03.)