Cytokines across the Night in Chronic Fatigue Syndrome with and without Fibromyalgia
[sb: I couldn't find this posted anywhere. Broderick's latest is with Klimas' cohort I think]
Toru Nakamura,1,2 Stephan K. Schwander,3* Robert Donnelly,3 Felix Ortega,3 Fumiharu Togo,4 Gordon Broderick,5 Yoshiharu Yamamoto,6 Neil S. Cherniack,1,3,{dagger} David Rapoport,7 and Benjamin H. Natelson1,2*
Pain & Fatigue Study Center,1 Departments of Neurosciences,2 Medicine, UMDNJNew Jersey Medical School, Newark, New Jersey 07103,3 Department of Work Stress Control, Japan National Institute of Occupational Safety and Health, Kawasaki 214-8585, Japan,4 Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada,5 Educational Physiology Laboratory, Graduate School of Education, The University of Tokyo, Tokyo, Japan,6 Department of Medicine, Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, New York, New York 100167
Received 22 September 2009/ Returned for modification 4 November 2009/ Accepted 12 February 2010
The symptoms of chronic fatigue syndrome (CFS) are consistent with cytokine dysregulation. This has led to the hypothesis of immune dysregulation as the cause of this illness. To further test this hypothesis, we did repeated blood sampling for cytokines while patients and matched healthy controls slept in the sleep lab. Because no one method for assaying cytokines is acknowledged to be better than another, we assayed for protein in serum, message in peripheral blood lymphocytes (PBLs), and function in resting and stimulated PBLs. We found no evidence of proinflammatory cytokine upregulation. Instead, in line with some of our earlier studies, we did find some evidence to support a role for an increase in interleukin-10, an anti-inflammatory cytokine. Although the changes were small, they may contribute to the common complaint in CFS patients of disrupted sleep.
Clinical and Vaccine Immunology, April 2010, p. 582-587, Vol. 17, No. 4
1071-412X/10/$12.00+0 doi:10.1128/CVI.00379-09
Copyright 2010, American Society for Microbiology. All Rights Reserved.
[sb: I couldn't find this posted anywhere. Broderick's latest is with Klimas' cohort I think]
Toru Nakamura,1,2 Stephan K. Schwander,3* Robert Donnelly,3 Felix Ortega,3 Fumiharu Togo,4 Gordon Broderick,5 Yoshiharu Yamamoto,6 Neil S. Cherniack,1,3,{dagger} David Rapoport,7 and Benjamin H. Natelson1,2*
Pain & Fatigue Study Center,1 Departments of Neurosciences,2 Medicine, UMDNJNew Jersey Medical School, Newark, New Jersey 07103,3 Department of Work Stress Control, Japan National Institute of Occupational Safety and Health, Kawasaki 214-8585, Japan,4 Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada,5 Educational Physiology Laboratory, Graduate School of Education, The University of Tokyo, Tokyo, Japan,6 Department of Medicine, Division of Pulmonary and Critical Care Medicine, NYU School of Medicine, New York, New York 100167
Received 22 September 2009/ Returned for modification 4 November 2009/ Accepted 12 February 2010
The symptoms of chronic fatigue syndrome (CFS) are consistent with cytokine dysregulation. This has led to the hypothesis of immune dysregulation as the cause of this illness. To further test this hypothesis, we did repeated blood sampling for cytokines while patients and matched healthy controls slept in the sleep lab. Because no one method for assaying cytokines is acknowledged to be better than another, we assayed for protein in serum, message in peripheral blood lymphocytes (PBLs), and function in resting and stimulated PBLs. We found no evidence of proinflammatory cytokine upregulation. Instead, in line with some of our earlier studies, we did find some evidence to support a role for an increase in interleukin-10, an anti-inflammatory cytokine. Although the changes were small, they may contribute to the common complaint in CFS patients of disrupted sleep.
Clinical and Vaccine Immunology, April 2010, p. 582-587, Vol. 17, No. 4
1071-412X/10/$12.00+0 doi:10.1128/CVI.00379-09
Copyright 2010, American Society for Microbiology. All Rights Reserved.