Coxsackie A?

[sometexan84]

@Hip need to extract some information from your noggin...

We always talk about Coxsackie B, but what about Coxsackie A?

I have abnormal results w/ high titers of Coxsackie A IgG, but have never researched "A" before.

My labcorp results...

LabCorp uses IFA for this test. Not sure how reliable this is, or what it means, or if maybe there's cross-reactivity w/ my active Coxsackie B infections?

This test was actually ordered by mistake... never thought to test this.

Any info you, or anyone, has on Coxsackie A?

 

[Judee]

This test was actually ordered by mistake... never thought to test this.

Can't help you with the analysis...not got a smart enough "noggin" (Sorry )

However, looking at those numbers maybe it was a good thing it was ordered "by mistake."

 

[Hip]

We always talk about Coxsackie B, but what about Coxsackie A?

I've never seen any studies showing that coxsackievirus A is involved with ME/CFS, or involved in any chronic disease of any sort. (If you can find any studies showing CVA is linked to chronic disease, I'd be very interested, but I have not been able to find any).

Whereas coxsackievirus B is linked to several chronic diseases, including ME/CFS, type 1 diabetes (chronic CVB infection of the insulin-producing cells), chronic myocarditis, dilated cardiomyopathy, Sjögren's syndrome, etc.


So for whatever reason, CVA does not seem to come up on the radar in the context of chronic disease. I do not know why; maybe it is because CVA does not form these persistent non-cytolytic infections as readily as CVB and echovirus do.

 

[sometexan84]

I've never seen any studies showing that coxsackievirus A is involved with ME/CFS, or involved in any chronic disease of any sort. (If you can find any studies showing CVA is linked to chronic disease, I'd be very interested, but I have not been able to find any).

Whereas coxsackievirus B is linked to several chronic diseases, including ME/CFS, type 1 diabetes (chronic CVB infection of the insulin-producing cells), chronic myocarditis, dilated cardiomyopathy, Sjögren's syndrome, etc.


So for whatever reason, CVA does not seem to come up on the radar in the context of chronic disease. I do not know why; maybe it is because CVA does not form these persistent non-cytolytic infections as readily as CVB and echovirus do.

Well, in my case, I think Google thinks I just want to see Coxsackie B related material, making it slightly more difficult to actually Google what I am now looking for

 

[Hip]

One interesting CVA serotype is coxsackievirus A9.

In the new enterovirus taxonomy, CVA9 is actually placed within the enterovirus B species, along with all the coxsackievirus Bs and echoviruses. We know that enterovirus B can form persistent non-cytolytic infections.

All the other CVAs are found either in enterovirus A, or enterovirus C.


So I wonder if CVA9 is similar to coxsackievirus B, and might form persistent non-cytolytic infections?

 

[sometexan84]

Huh, how about that.

Some adults w/ dermatological manifestations (skin issues) from Coxsackie A6 had long-term symptoms at 2-yr follow up.

Looks like Coxsackie A can in fact become a low-level persistent infection (just that most no longer had it detectable in plasma at follow-up, but we know this is to be expected if following suit with CVB).

AND, a bunch of these cases had "CFS" and/or "persistent myalgia".

https://www.jaad.org/article/S0190-9622(18)32488-5/fulltext

"case 3 developed degenerative mitral valve disease and maintained low-level CV-A6 viremia, indicating that the virus had established low-level persistence in the host; cases 2, 8, and 10 developed persistent myalgia/arthralgia"

 

[Hip]

https://www.jaad.org/article/S0190-9622(18)32488-5/fulltext

That study is an interesting find. Table 1 indicates that 2 people out of 10 with CVA6 infection went on to develop ME/CFS.

Maybe this is something Dr Chia might be interested in.

 

[Hip]

There is some suggestion that acyclovir (and no doubt its prodrug Valtrex) works against coxsackievirus A.

 

[sometexan84]

That study is an interesting find. Table 1 indicates that 2 people out of 10 with CVA6 infection went on to develop ME/CFS.

Maybe this is something Dr Chia might be interested in.

Bizarre. I certainly was not expecting to see any mention of ME/CFS in the article. Wasn't searching for CFS at all.

 

[sometexan84]

Also seems that Coxsackie A might be related to rashes, which I've had...

 

[Pyrrhus]

Enterovirus A71 evolved from Coxsackie A16 at some point between 1929-1952, so I would consider Coxsackie A16 to potentially be a serious persistent infection:

Evolutionary Genetics of Human Enterovirus 71: Origin, Population Dynamics, Natural Selection, and Seasonal Periodicity of the VP1 Gene
https://journals.asm.org/doi/full/10.1128/JVI.01019-09

 

[Hip]

LabCorp uses IFA for this test.

I wonder why LabCorp uses IFA for its coxsackievirus A antibody test, but complement fixation (CF) for its coxsackievirus B antibody test?

I gather from Dr Chia's videos that CF is the least sensitive for chronic infection. I think the IFA and ELISA methods are a bit more sensitive, but not as sensitive as the gold standard neutralization method of detecting antibodies.


I notice also that the LabCorp CVA IFA antibody test comes in two varieties: IgM and IgG antibodies.

Whereas the LabCorp CVB CF antibody test does not specify whether it is IgM or IgG, which I think usually means that it detects both types of antibody at once, pooling both together (neutralization tests are usually like this also: they do not detect IgM or IgG individually, but pool both together).

 

[sometexan84]

I wonder why LabCorp uses IFA for its coxsackievirus A antibody test, but complement fixation (CF) for its coxsackievirus B antibody test?

That's so funny, this is exactly what I was going to ask when I got back to the forum today. Great minds think alike.