Could my problem be Pyruvic/Lactic acid issues?
- Thread starter Belbyr
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Judee
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I think it's part of the ATP cycle so it might make sense that you could be low. I'm not sure how you could raise it though.
I tried taking some pyruvates in mineral form (I think it was calcium pyruvate) and that just made my dreams very loud. It was a strange sensation as though someone had turned up the audio volume of my dreams so I stopped taking it. Plus, it it did nothing for my energy levels.
Hope someone else will be able to give you more scientific thoughts than mine.
I tried taking some pyruvates in mineral form (I think it was calcium pyruvate) and that just made my dreams very loud. It was a strange sensation as though someone had turned up the audio volume of my dreams so I stopped taking it. Plus, it it did nothing for my energy levels.
Hope someone else will be able to give you more scientific thoughts than mine.
Zebra
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It *could* be something, and it's certainly worth ruling out.
To investigate further you would need a new blood draw that measure both levels, and, much more importantly, for the lab to determine your lactate to pyruvate ratio.
As a starting point, check out this info from Mayo Clinic Labs.
https://neurology.testcatalog.org/show/PYR
How's your work up coming along? Last time we chatted you were considering a muscle bx and on the wait list to see a really good neuro.
The neuro could order this test on your blood. If it came back suspicious for primary mitochondrial disease, the test could be repeated on your CSF for confirmation.
To investigate further you would need a new blood draw that measure both levels, and, much more importantly, for the lab to determine your lactate to pyruvate ratio.
As a starting point, check out this info from Mayo Clinic Labs.
https://neurology.testcatalog.org/show/PYR
How's your work up coming along? Last time we chatted you were considering a muscle bx and on the wait list to see a really good neuro.
The neuro could order this test on your blood. If it came back suspicious for primary mitochondrial disease, the test could be repeated on your CSF for confirmation.
The blood draw that showed the low pyruvate showed very elevated lactate but still barely within the normal range. I do know my lactate always seems high whenever it is tested.
The Neuro I was seeing canceled my muscle biopsy and said, "you just have POTS, I can't help you".
As far as the workup, I have had to fire my local doctor and start with a new one. I'm also no longer working with NOVA, nice people but no results/treatment.
Right now I'm planning on doing some of these Mayo tests for autoantibodies and maybe going back to seeing one of the 'big' POTS specialists since I have not seen one for about 3.5-4 years now and I know research has revealed a lot of stuff over that time.
I think we have everything nailed down to pretty much my smooth muscle is the issue. (Gi tract and circulation). I think my kidneys are doing poorly because of the increased blood pressure I'm having from POTS. I'll confirm that with nephrology in early October.
The Neuro I was seeing canceled my muscle biopsy and said, "you just have POTS, I can't help you".
As far as the workup, I have had to fire my local doctor and start with a new one. I'm also no longer working with NOVA, nice people but no results/treatment.
Right now I'm planning on doing some of these Mayo tests for autoantibodies and maybe going back to seeing one of the 'big' POTS specialists since I have not seen one for about 3.5-4 years now and I know research has revealed a lot of stuff over that time.
I think we have everything nailed down to pretty much my smooth muscle is the issue. (Gi tract and circulation). I think my kidneys are doing poorly because of the increased blood pressure I'm having from POTS. I'll confirm that with nephrology in early October.
vision blue
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Altered lactate pyravute ratios can be at the root of your illneess (meaning a marker for the muscle and other problems going on) , including resulting in POTS. I assume you are searching for mitochondrial problems?
Zebra
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@Belbyr
To follow-up on @vision blues comment, the link I posted above explains the significance of lactate pyruvate ratios in the setting of primary metabolic or mitochondrial diseases.
To follow-up on @vision blues comment, the link I posted above explains the significance of lactate pyruvate ratios in the setting of primary metabolic or mitochondrial diseases.
Yes but can't really seem to find a doctor for mito issues, it seems like a mysterious medical field. I don't even know what the treatment would be if I do in fact have it?
Dechi
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I’m no expert but if your value is 0.2 and the normal range is 0.3, then mostly it’s considered in the range of normal. Any test I have that’s as close to the normal range I was told it was normal. But then again, everything is always normal to them...
The more I read on it, the more it seems to cause big issues starting from birth. I think hearing Ron Davis talk about it sparked my interest.
Learner1
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Mito expert Fran Kendall is in Atlanta if you think you have mitochondrial disease. She does telemedicine consults.
I will look into it, thanks!