lansbergen
Senior Member
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I think I found why dexamethasone worsened the problem
http://www.fasebj.org/content/16/1/61.full#sec-1
Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells
First, at the gene cluster level, our study shows a bidirectional action of GC, which are both immunostimulatory and immunosuppressive at the same time even for the inflammation cluster (12)⇓. They seemed to prime and enhance the innate immune response while repressing part of the adaptive immune response in a resting state. This suggests that GC help clear antigens by stimulating cell trafficking, scavenger systems, and matrix metalloproteinases while they halt cellular immune responses by inhibiting antigen presentation and T cell activation.
http://www.fasebj.org/content/16/1/61.full#sec-1
Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells
First, at the gene cluster level, our study shows a bidirectional action of GC, which are both immunostimulatory and immunosuppressive at the same time even for the inflammation cluster (12)⇓. They seemed to prime and enhance the innate immune response while repressing part of the adaptive immune response in a resting state. This suggests that GC help clear antigens by stimulating cell trafficking, scavenger systems, and matrix metalloproteinases while they halt cellular immune responses by inhibiting antigen presentation and T cell activation.