I've been on this website for a year now but am just getting around to feeling like Im familiar enough to post. I'm detoxing so I can start methylating without too many side effects. My specific question is around that on converting Oxidized Glutathione back to Reduced Glutathione. Also if your not converting Oxidized back to reduced is it bad to do things to stimulate reduced glutathione eg. coffee enema and other methods, can I build up too much oxidized trying to get the reduced numbers up, kinda like trying to methylate before detoxing?
I took the Methylation pathway analysis test from seeking health, revealed low Reduced Gluta and High Oxidized. My question is what supplements could be beneficial in that conversion i know one of the vital enzymes for doing so is NADHP(which might also explain my low active folate and MTHFR mutation), Could it be as easy as taking NADH from source naturals now all it needs is a phosphorus molecule which my phosphorus is low on Hair EE and OATS.
Dr. ben lynch also suggested i take selenium, resveratrol, Vitamin E, PC, and curium, however I could find no literature supporting this. I know the CBS +/+ is implicated in the impaired glutathione production however I'm a bit A typical in that that flow to my transsulfuration pathway is low. Any knowledge or insight to this area would be greatly valued.
Anyway incase needed or curious here is my information
My mutations are as follows…(post viral fatigue since Aug 12' 24 yr. old Male)
MAO A +/+
--------------------
CBS (C699T) +/+
--------------------
SHMT +/+
--------------------
ACAT +/-
--------------------
MTHFR (C677T) +/-
--------------------
MTR (A2756G) +/_
--------------------
MTRR (A66G) +/-
--------------------
MTRR(11) +/-
--------------------
BHMT 2 +/-
--------------------
BHMT 4 +/-
--------------------
BHMT 8 +/-
--------------------
CBS (A360A) +/-
Methylation Pathway Panel
Glutathione (oxidized) 0.58 (.16-0.50)
Glutathione (reduced) 3.8 (3.8-5.5)
----------------------------------------------------
SAM-E… 223 (221-256)
SAH……. 56.4 (38-49)
--------------------------------------------------
5-CH3-THF …….….14.3 (8.4-72.6)
10-Formyl-THF…. 8.5 (1.5-8.2)
5-Formyl-THF…….2.0 (1.20-11.7)
THF……………………0.67(.60-6.80)
Folic Acid…………..16.6 (8.9-24.6)
Folinic Acid (WB)..10.2 (9.0-35.5)
Active Folate…… 361 (400-1500)
----------------------------------------------------
Adenosine ……….26.9 (16.8-21.4)
Borderline high Methionine 3.3 (1.6-3.6) per Amino Acid Plasma
Borderline High Homocystine .41 (<.50)
However my Ammonia isn’t bad 18 (<30)
I took the Methylation pathway analysis test from seeking health, revealed low Reduced Gluta and High Oxidized. My question is what supplements could be beneficial in that conversion i know one of the vital enzymes for doing so is NADHP(which might also explain my low active folate and MTHFR mutation), Could it be as easy as taking NADH from source naturals now all it needs is a phosphorus molecule which my phosphorus is low on Hair EE and OATS.
Dr. ben lynch also suggested i take selenium, resveratrol, Vitamin E, PC, and curium, however I could find no literature supporting this. I know the CBS +/+ is implicated in the impaired glutathione production however I'm a bit A typical in that that flow to my transsulfuration pathway is low. Any knowledge or insight to this area would be greatly valued.
Anyway incase needed or curious here is my information
My mutations are as follows…(post viral fatigue since Aug 12' 24 yr. old Male)
MAO A +/+
--------------------
CBS (C699T) +/+
--------------------
SHMT +/+
--------------------
ACAT +/-
--------------------
MTHFR (C677T) +/-
--------------------
MTR (A2756G) +/_
--------------------
MTRR (A66G) +/-
--------------------
MTRR(11) +/-
--------------------
BHMT 2 +/-
--------------------
BHMT 4 +/-
--------------------
BHMT 8 +/-
--------------------
CBS (A360A) +/-
Methylation Pathway Panel
Glutathione (oxidized) 0.58 (.16-0.50)
Glutathione (reduced) 3.8 (3.8-5.5)
----------------------------------------------------
SAM-E… 223 (221-256)
SAH……. 56.4 (38-49)
--------------------------------------------------
5-CH3-THF …….….14.3 (8.4-72.6)
10-Formyl-THF…. 8.5 (1.5-8.2)
5-Formyl-THF…….2.0 (1.20-11.7)
THF……………………0.67(.60-6.80)
Folic Acid…………..16.6 (8.9-24.6)
Folinic Acid (WB)..10.2 (9.0-35.5)
Active Folate…… 361 (400-1500)
----------------------------------------------------
Adenosine ……….26.9 (16.8-21.4)
Borderline high Methionine 3.3 (1.6-3.6) per Amino Acid Plasma
Borderline High Homocystine .41 (<.50)
However my Ammonia isn’t bad 18 (<30)
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