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The Freddd methylation protocol was developed by a PR member named Freddd who has some interesting genetics. People around here tend to use it as a "one size fits all" protocol, which is not the best idea.
Methylation is a process that happens in our cells, and is essential for proper immune system function, DNA replication, neurotransmitter production, detoxification, cell membrane health, etc.
It involves folate, B12, B2, B6, trimethylglycine, magnesium, potassium, methionine, and other nutrients, and produces glutathione, an important antioxidant used in immune function and detoxification.
Depending upon the mix of genetic SNPs you were born with affecting methylation, your environmental exposures, which place demands on it, as well as competition by other body biochemical processes for the various nutrients, your needs for these nutrients will be unique to you, and its highly likely not what Freddd found worked for him. (His protocol would make me quite sick.)
Having an imbalanced or inadequate methylation process can produce a plethora of unpleasant symptoms and promote disease, even cancer. It's very wise to have comprehensive nutrient testing to guide dosing of nutrients, like a Genova Diagnostics NutrEval test.
As you implement it, its wise to ensure the toxins you begin to mobilize are eliminated easily through your intestines. Drinking water, eating fiber, and using binders are strategies that help, as well as attending to your microbiome. Having adequate B1 and molybdenum and having adequate protein (amino acid) intake are essential, too.
Your needs will likely change over time, so adjusting your protocol every few months is wise.
There are a lot of resources on this site and across the internet for learning more.
Oh thank you Learner that's a really good explanation! I've been told I'm homozygous for the MTHFR genetic deficiency thingo, and I know that affects methylation, so I've been taking glutathione daily. The NutrEval test sounds like a good idea. Just need to save up and decide which tests to get! I'll do some more research to find the right protocol for me.