Comparative Analysis of Extracellular Vesicles in Patients with Severe and Mild Myalgic Encephalomyelitis/Chronic Fatigue Syn... (Bonilla et al, 2022)

Consul

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Comparative Analysis of Extracellular Vesicles in Patients with Severe and Mild Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Bonilla et al, 2022


Abstract

Myalgic encephalomyelitis, or chronic fatigue syndrome (ME/CFS) is a serious disease whose cause has yet to be identified. Objective markers of the disease are also not well understood and would serve as important tools in diagnosis and management. One potential biomarker or transmitter of immune signals in ME/CFS is the extracellular vesicle (EV) compartment. These small, membrane bound particles have been shown to play a key role in intercellular signaling. Our laboratory has focused on methods of detection of EVS in clinical samples. In this study we explored whether the prevalence of EVs in the plasma of participants with mild or severe ME/CFS differed from the plasma of healthy control participants. By staining for multiple cell surface molecules, plasma EVs could be fingerprinted as to their cell of origin. Our study revealed a significant correlation between severe ME/CSF and levels of EVs bearing the B cell marker CD19 and the platelet marker CD41a, though these changes were not significant after correction for multiple comparisons. These findings point to potential dysregulation of B cell and platelet activation or homeostasis in ME/CFS, which warrants validation in a replication cohort and further exploration of potential mechanisms underlying the association.


The study: https://pubmed.ncbi.nlm.nih.gov/35309313/
 
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A study included Mild patients!??? Wow.

I was mild for 58 years. Its odd, to know you were affected by something depreciating for that long, yet nobody ever speaks to what is happening in mild ME.
 

Wishful

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I skimmed the article, but can't judge its value. However, I expect that ME's root cause will turn out to be something that hard to find. I agree that it's probably worth further investigation.
 

Wishful

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How much does it matter that the findings were insignificant?
Well, it could avoid wasting limited funding on further research. Without this data, someone else might convince someone to fund this same research. There seem to be plenty of people who get genetic testing done seemingly in the hope that it will reveal some SNP to be the 'THE ANSWER!'

They found some correlation. Is it significant? Only further research would answer that question.
 
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