pattismith
Senior Member
- Messages
- 3,955
I happened to discover accidentally that low dose Colchicine + low dose Piroxicam (non selective cox inhibitor) give me instant relief from my brain fog/fatigue/sleepiness.CLINICAL IMPROVEMENT IN PATIENTS WITH ME/CFS WITH SYNERGISTIC EFFECT OF COLCHICINE AND SPIRONOLACTONE TARGETING INHIBITION OF INFLAMMASOME ACTIVITY
https://onlinelibrary.wiley.com/doi/10.1111/imj.23_15766
The starting dose of Spironolactone was 12.5 mg a day increased to 25 mg a day (during years 2019 to 2021). The introduction of Colchicine 0.5 mg/day on treatment plan was during year 2021. Patient follow-up was in the outpatient clinic and GP clinic.
Results: Total 23 Patients 19 were Females age 37.3+28 and 4 were Males age 61+9. Two patients stop colchicine after 4 weeks. Improvement in cognitive skills was the early manifestation of spironolactone benefit. Patients reported to be less brain foggy, more alert, and they found it easier to focus when doing normal everyday activities.
They were also less irritable by noise and light and described themselves to be able to multi-task again. There was an improvement in general condition and everyday activities four weeks after Colchicine started.
After a quick research I found Dr Montoya was using Colchicine in his treatment and also Dr Chia was using the combo Indometacine/Colchicine: it's very close to my Piroxicam/Colchicine combo.
My trial is currently Colchicine 0.25 mg + Piroxicam 5 mg per day.
My husband who suffers with hypersomnia took it as well and felt an instant relief too (he suffers from aging, cancer and post chemotherapy fatigue).
Low dose Colchicine is currently include in the cardiology European Guidelines:
https://eso-stroke.org/cytokines-and-stroke-worst-enemies-or-best-friends/Accordingly, new 2021 European Society of Cardiology (ESC) guidelines recommend low-dose of colchicine (0.5 mg daily) for secondary prevention of cardiovascular diseases, particularly if other risk factors are insufficiently controlled or if recurrent cardiovascular disease events occur under optimal therapy (Class IIb, Level A) 9