http://naviauxlab.ucsd.edu/team/He is a Salk-trained virologist, and molecular and cell biologist, the inventor of the popular pCL retroviral gene transfer vectors, and was trained at NIH in tumor immunology and natural killer cell biology.
latent and reactivated viral and bacterial infections can occur, but in the case of ME/CFS that has lasted for more than 6 months, this may be the exception rather than the rule.
Some doctors and scientists have not done a good job at educating patients and other scientists about the difference between serological evidence of infection in the form of antibodies like IgM and IgG, and physical evidence of viral replication like PCR amplification of viral RNA or DNA, or bacterial DNA.
We have learned in our autism studies with Dr. Judy Van de Water that supertiters of antibodies do not mean new or reactivated viral replication. Supertiters of IgG antibodies mean that the balancing T-cell and NK cell mediated immune activity is decreased.
This is a functional kind of immune deficiency that causes an unbalanced increase in antibodies.[/QUOTE]
My doctors also ran CMV and EBV PCR tests.
They also ran IgA on all of the above.
Have you had immunoglobulins measured?
What did your doctor say? Are you getting treatment for any of these?
This what Dr. Robert Naviaux says about high antibody titers in CFS.
Increased IgG antibodies to CMV, EBV, HHV6, Coxsackie, etc. are not good evidence of a reactivated viral infection. While Coxsackie is an RNA virus related to poliovirus, antibody titers can increase to this virus too, even though it cannot establish a chronic or latent infection. This can be proven in most cases by trying to measure viral DNA or RNA by PCR in the blood or swollen lymph nodes.
in this article it states in CMV reactivation at acute stage IGG titers rise to Four Fold.
Can we use this for diagnosing our CMV reactivation?
Looking for CMV test criteria ME doctors use yes. I can’t seem to find anything specific.
Thank you. Yes it’s adding up to all three it seems which the more I learn the more I am told ther ride together. Am in middle of evaluation with ME doctor but that CMV I wanted to research. Like you said Dr L wasn’t clear on threshold. Yes it’s quite positively H High.@SunMoonsStars, I think your HHV6 IgG titers of 1:1280 would indicate an active infection by Dr Montoya's criteria. But ideally you would want to see an ME/CFS specialist doctor to get a diagnosis of active infection in these 3 viruses.
Valcyte is an antiviral which targets EBV, HHV-6 and CMV.
Also, there is a common misunderstanding about viral infection among some patients and even some doctors. Most viral assays used by doctors test for the presence of antibodies to viruses, not the viruses themselves.
The presence of antibodies shows that the person had a viral infection in the past, but does not constitute evidence that it is still present.
A direct assay for a virus is needed in order to find out if any virus is present. The current state-of-the-art assay is a PCR test for DNA or RNA from a virus. (Serology tests are tests for antibodies, not viruses.)
We are conducting these direct PCR assays in the Severely Ill Patient Study, as well as extensive DNA sequencing for any as-yet-undiscovered viruses.