aquariusgirl
Senior Member
- Messages
- 1,732
Anyone got any rare SNPs on this gene?
Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism (PubMed:29056341). Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway (PubMed:29056341). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed:29056341). Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate (PubMed:24334609, PubMed:29056341). Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate (PubMed:24334609, PubMed:29056341). Also has very weak citramalate synthase activity in vitro (PubMed:24334609, PubMed:29056341).2 Publications
Catalytic activityi
Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.2 Publications
Propionyl-CoA + H2O + glyoxylate = beta-methylmalate + CoA.2 Publications
(3S)-citramalyl-CoA = acetyl-CoA + pyruvate.1 Publication
Cofactori
Mg2+2 PublicationsNote: Binds 1 Mg2+ ion per subunit.1 Publication
Kineticsi
Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism (PubMed:29056341). Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway (PubMed:29056341). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed:29056341). Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate (PubMed:24334609, PubMed:29056341). Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate (PubMed:24334609, PubMed:29056341). Also has very weak citramalate synthase activity in vitro (PubMed:24334609, PubMed:29056341).2 Publications
Catalytic activityi
Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.2 Publications
Propionyl-CoA + H2O + glyoxylate = beta-methylmalate + CoA.2 Publications
(3S)-citramalyl-CoA = acetyl-CoA + pyruvate.1 Publication
Cofactori
Mg2+2 PublicationsNote: Binds 1 Mg2+ ion per subunit.1 Publication
Kineticsi
Last edited: