Am I some sort of freak???.... Or what because I had a similar reaction to clonidine as I did to amitryptyline. Yes, I know they are in a completely different class of medications, but I took Clonidine 0.1mg and NO SLEEP just like when I took Amitryptyline. It did something to my brain. Could Clonidine actually have increased norephinephrine in my case?