It might not be safe to assume high norepinephrine is causing your anxiety or other problems. In my case, norepinehprine is very low - and effectively raising it (with an SNRI) helps a lot with my symptoms.Am I some sort of freak???.... Or what because I had a similar reaction to clonidine as I did to amitryptyline. Yes, I know they are in a completely different class of medications, but I took Clonidine 0.1mg and NO SLEEP just like when I took Amitryptyline. It did something to my brain. Could Clonidine actually have increased norephinephrine in my case?