I have a rudimentary understanding of biochemistry and in brain fog right now so tricky to hold all the thoughts in my head that aren't part of my previous educational background
but I have noticed that cholinergic treatments have been discussed as probably helpful for myelin repair such as ace inhibitors
http://en.wikipedia.org/wiki/Myelin
"Demyelination is the loss of the myelin sheath insulating the nerves, and is the hallmark of some neurodegenerative autoimmune diseases,"
and I think tnf inhibitors may be indicated? I know they are tossed about as good for ME/CFs and autoimmune, right?
but on the other hand Jay Goldstein recommends for CFS and pain etc combatting histamines because they probably stimulate the NMDA receptors which most experts think we shouldn't do, also correct? NMDA inhibition big idea for CFS I think? So that is why benadryl and other antihistamines often give some relief of symptoms and help with sleep etc
Yet, benadryl an anticholinergic which is the opposite of what we want to be doing if a myelin problem, as want pro-cholinergic ?
I am struggling with these competing needs right now as have been using benadryl for sleep and MCS and its the med I can tolerate the best for insomnia yet its anticholinergic effects are worsening my dry eye problem I have with sjogrens. Its very concerning because I have corneal erosion and one eye is constantly blurring and getting recurrent abrasions. yet if I don't take the benadryl at nite I may not sleep and I still work so have to manipulate sleep or will be a mess at the office.
I don't understand that, how our body/brains seem to like chemicals that are both good and bad for us. what does that mean? (hah sorry if that sounds like forest gump or something, thats the science level I operate at)
any info appreciated!
best
XrS
but I have noticed that cholinergic treatments have been discussed as probably helpful for myelin repair such as ace inhibitors
http://en.wikipedia.org/wiki/Myelin
"Demyelination is the loss of the myelin sheath insulating the nerves, and is the hallmark of some neurodegenerative autoimmune diseases,"
and I think tnf inhibitors may be indicated? I know they are tossed about as good for ME/CFs and autoimmune, right?
but on the other hand Jay Goldstein recommends for CFS and pain etc combatting histamines because they probably stimulate the NMDA receptors which most experts think we shouldn't do, also correct? NMDA inhibition big idea for CFS I think? So that is why benadryl and other antihistamines often give some relief of symptoms and help with sleep etc
Yet, benadryl an anticholinergic which is the opposite of what we want to be doing if a myelin problem, as want pro-cholinergic ?
I am struggling with these competing needs right now as have been using benadryl for sleep and MCS and its the med I can tolerate the best for insomnia yet its anticholinergic effects are worsening my dry eye problem I have with sjogrens. Its very concerning because I have corneal erosion and one eye is constantly blurring and getting recurrent abrasions. yet if I don't take the benadryl at nite I may not sleep and I still work so have to manipulate sleep or will be a mess at the office.
I don't understand that, how our body/brains seem to like chemicals that are both good and bad for us. what does that mean? (hah sorry if that sounds like forest gump or something, thats the science level I operate at)
any info appreciated!
best
XrS