Talking About Papers
Talking about papers that have been published and not published . . .
There are 5 negitive studies that do not correlate CFS and XMRV according to Dr. Ruscetti
1- Erlwein O, Kaye S, McClure MO, Weber J, Wills G, Collier D, Wessely S, Cleare A.
PLoS One. 2010 Jan 6 Total 0 CFS 0 HC
2-Groom HC, Boucherit VC, Makinson K, Randal E, Baptista S, Hagan S, Gow JW, Mattes FM, Breuer J, Kerr JR, Stoye JP, Bishop KN.
Retrovirology. 2010 Feb 15 Total 1 CFS and 4 HC
3-van Kuppeveld FJ, de Jong AS, Lanke KH, Verhaegh GW, Melchers WJ, Swanink CM, Bleijenberg G, Netea MG, Galama JM, van der Meer JW.
BMJ. 2010 Feb 25 Total 0 CFS and 0 HC *
(*caveat is that WPI found 2 XMRV positive from 10 samples sent to them by Van Kupperveld which was omitted from the original paper)
4-The Hubner study which has not been published at this time but which was leaked by Dr. Hubner and is reportedly a zero/zero study
5- The CDC paper which was completed early on and is a zero/zero paper
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According to Frank Ruscetti there are "three" positive papers. We know the first one
1-Lombardi VC, Ruscetti FW, Das Gupta J, Pfost MA, Hagen KS, Peterson DL, Ruscetti SK, Bagni RK, Petrow-Sadowski C, Gold B, Dean M, Silverman RH, Mikovits JA.
Science. 2009 Oct 23;326(5952):585-9. Epub 2009 Oct 8. Total 68 CFS 8 HC **
But what are the other two? Is FDA/NIH one study or two? And if it's one then what is the other study? Dr. Ruscetti isn't going to tell a bunch of researchers that there are two more studies that link CFS/XMRV just to fill up time.
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There are two additional studies often referenced by Dr. Mikovitz in talks reporting numbers in FAMILIAL illnesses including CFS families with members who have Autisum, MS, and Fibromyalgia this paper has been ready for publication and passed peer review, according to Dr. Mikovitz since February and a second study that uses the same Science cohort that reports a 98% incidence of XMRV in CFS patients that has also been review and ready to be publish since February.
Where are they?
In addition to this the Dr.'s Light / Bateman have a study that they started in March which is a patient cohort of 200. (See CBS for more information)
And the Glaxo-Smith-Klien study that was started end of March or 1st of April.
This is a list of the papers to be presented at Cold Springs Harbor Laboratory (thanks for the correction, grins)
From
http://www.virology.ws/2010/05/07/xmrv-at-cold-spring-harbor/
One of these is the meeting on retroviruses, which will begin on 24 May 2010. Below is a list of the presentations about XMRV, the new retrovirus implicated in prostate cancer and chronic fatigue syndrome. The author presenting each study can be found at the meeting website.
Failure to detect XMRV in human prostate tumors
Development of a multiplex serological assay to detect XMRV antibodies
Characterization of cellular determinants required for infection of XMRV, a novel retrovirus associated with human familial prostate cancer
Screening mouse genomes For XMRV-Like Elements
Development of highly sensitive assays for the detection of XMRV nucleic acids in clinical samples
Compounds that inhibit replication of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome
Investigation of XMRV as a human pathogen
Investigations into XMLV-related virus infection
XMRV is not detected in Quebec patients with chronic fatigue syndrome
Wild-derived mouse strain (Mus pahari) as a small animal model for XMRV infection
XMRV tropism in hematopoietic cells
Evidence for sequence variation in XMRV
The human retrovirus XMRV produces rare transformation events in cell culture but does not have direct transforming activity
The XMRV is inhibited by APOBEC3 proteins and anti-HIV-1 drugs
Immune responses in XMRV-infected rhesus macaques—Serological markers of XMRV infection
XMRV Is inhibited by interferon independently of RNase L or Tetherin
Comparison of XMRV infections in humans and rhesus macaques
Susceptibility of XMRV to antiretroviral inhibitors
Integration site analysis in XMRV-positive prostate cancers
Xpr1 is necessary but not sufficient for XMRV entry
Effects of interferon regulated proteins, RNase L and APOBEC3G, on XMRV replication
The retrovirus community has clearly embraced XMRV, a virus discovered just four years ago. This high level of activity means that there will be many papers on XMRV in the scientific literature in the next year. I’m looking forward to discussing them with the readers of virology blog.
(big dog sigh) Where have all the papers gone? I swear I didn't eat them!